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PMID: 468261 Published · ppublish English Case Reports Journal Article Research Support, U.S. Gov't, P.H.S.

Position of the human X inactivation center on Xq.

Human genetics ·Vol. 50 ·No. 1 ·1979-00-00 ·Pages 59-64

Therman E, Sarto GE, Palmer CG, Kallio H, Denniston C

Abstract

In three women with a 46,XXq- chromosome constitution, the length of the deletion was expressed as the ratio of the remaining part of Xq to Xp c' over a + b. In one of them (KH) this ratio was 0.33, in another (GE) 0.59, and in the third (AP) the ratio fell between these values. The break in KH is more or less on the border of the Q-dark proximal region. A comparison with relevant X-autosomal translocations indicates that the X inactivation center lies near, but not at the border of, the Q-dark and the adjoining bright region (c and d).

MeSH Terms
Adult Chromosome Banding Chromosome Deletion Chromosome Mapping Female Humans Sex Chromosome Aberrations/genetics Sex Chromosomes Translocation, Genetic Turner Syndrome/genetics X Chromosome
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Therman E
Sarto G E
Palmer C G
Kallio H
Denniston C
References (10)
10 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00295590
Published
1979-00-00
Pages
59-64
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00295590 View journal details
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