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PMID: 4677596 Published · ppublish English Journal Article

Silver sulfadiazine: interaction with isolated deoxyribonucleic acid.

Antimicrobial agents and chemotherapy ·Vol. 2 ·No. 5 ·1972-11-00 ·Pages 373-83

Rosenkranz HS, Rosenkranz S

Abstract

Silver sulfadiazine (AgSu) was found to interact with isolated deoxyribonucleic acid (DNA) to form nondissociable complexes. These complexes differ in physical and chemical properties from those that are established when silver nitrate is added to DNA. The reaction between AgSu and DNA is visualized as occurring in two stages: (i) a weak and reversible interaction (intercalation) between DNA and the sulfadiazine moiety and (ii) a tight binding involving the silver atom. In the first stage, sodium sulfadiazine competes with AgSu for the DNA.

MeSH Terms
Animals Cattle Centrifugation, Density Gradient Cesium DNA Silver Sucrose Sulfadiazine Thymus Gland/analysis
Chemicals
Sulfadiazine Cesium Silver Sucrose DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rosenkranz H S
Rosenkranz S
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21 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.2.5.373
Published
1972-11-00
Pages
373-83
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC444323
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.2.5.373 PMC Full Text View journal details
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