Blocking by picrotoxin of nigra-evoked inhibition of neurons of ventromedial nucleus of the thalamus.

Experientia ·Vol. 35 ·No. 6 ·1979-06-15 ·Pages 794

Yoshida M, Omata S

Abstract

The transmitter substance realeased by nigro-thalamic fibres is proposed to be gamma-aminobutyric acid, since picrotoxin blocked nigra-evoked monosynaptic inhibition of thalamic neurons.

MeSH Terms

Action Potentials/drug effects Animals Cats GABA Antagonists Neural Inhibition/drug effects Neural Pathways/drug effects Picrotoxin/pharmacology Substantia Nigra/physiology Thalamic Nuclei/physiology gamma-Aminobutyric Acid/physiology

Chemicals

GABA Antagonists Picrotoxin gamma-Aminobutyric Acid

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Yoshida M

Omata S

References (7)

7 references, click to expand

The inhibitory action of -aminobutyric acid, a probable synaptic transmitter.
Int Rev Neurobiol. 1972;15:167-87 PMID: 4347726
Blockage of caudate-evoked inhibition of neurons in the substantia nigra by picrotoxin.
Brain Res. 1971 Sep 10;32(1):229-33 PMID: 4329652
Monosynaptic inhibition of thalamic neurons produced by stimulation of the substantia nigra.
Experientia. 1977 Nov 15;33(11):1480-2 PMID: 923717
Caudate-evoked inhibition and actions of GABA and other substances on cat pallidal neurons.
Brain Res. 1973 Dec 21;64:455-9 PMID: 4360889
Monosynaptic inhibition of pallidal neurons by axon collaterals of caudato-nigral fibers.
Exp Brain Res. 1972;15(4):333-47 PMID: 5079469
GABA-picrotoxin interaction in the mammalian central nervous system.
Brain Res. 1969 Aug;14(3):763-7 PMID: 5822449
The mole of pallido-thalamic transmission investigated with intracellular recording from cat thalamus.
Exp Brain Res. 1978 Nov 15;33(3-4):493-507 PMID: 215434

Article Info

Journal

Experientia

Abbr.

Experientia

ISSN

0014-4754

DOI

10.1007/BF01968253

Published

1979-06-15

Pages

794

Language

English

Region

Switzerland

NLM ID

0376547

Subset

External Links

PubMed source DOI: 10.1007/BF01968253

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Blocking by picrotoxin of nigra-evoked inhibition of neurons of ventromedial nucleus of the thalamus.

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