Increased brain weight-liver weight ratio as a necropsy sign of intrauterine undernutrition.

Journal of clinical pathology ·Vol. 25 ·No. 10 ·1972-10-00 ·Pages 867-71

Anderson JM

Abstract

Comparison of the brain weight/liver weight ratio(1) with the body weight of 95 stillborn and neonatally deceased infants of gestation 25-42 weeks shows that in appropriately grown infants the mean value ratio is 2.8 and is unchanged with increasing maturity. The normal range is 1.7-4.1. Survival time has no significant effect on the ratio as studied in this necropsy population. Dysmature infants of body weight less than 1 SD below the mean body weight for gestation are characterized by a brain: liver weight ratio of 4.5 or more. On the basis of these observations the brain: liver weight ratio may be employed as a guide to the prenatal nutrition of infants at necropsy.

MeSH Terms

Autopsy Birth Weight Brain/pathology Estriol/urine Female Fetal Death/pathology Fetal Diseases/diagnosis,pathology Gestational Age Humans Infant Mortality Infant, Newborn Liver/pathology Nutrition Disorders/diagnosis,pathology Organ Size Pregnancy Pregnancy Complications Statistics as Topic

Chemicals

Estriol

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Anderson J M

References (16)

16 references, click to expand

Foetal growth retardation.
Br Med Bull. 1966 Jan;22(1):13-5 PMID: 5321808
Neonatal hypoglycaemia.
Br Med Bull. 1966 Jan;22(1):34-9 PMID: 5321812
The determination of normal ranges from routine laboratory data.
Clin Chem. 1968 Oct;14(10):979-88 PMID: 5676115
Head circumference and cellular growth of the brain in normal and marasmic children.
J Pediatr. 1969 May;74(5):774-8 PMID: 5778830
Low content of cerebral lipids in infants suffering from malnutrition.
Nature. 1969 Feb 8;221(5180):552-3 PMID: 5789300
Undernutrition and the developing brain. The relevance of animal models to the human problem.
Am J Dis Child. 1970 Nov;120(5):411-5 PMID: 5474747
Changes in brain weight, cholesterol, phospholipid, and DNA content in marasmic children.
Am J Clin Nutr. 1970 Oct;23(10):1275-9 PMID: 5475658
Very low birth-weight and subsequent head growth.
Lancet. 1970 Dec 12;2(7685):1216-9 PMID: 4099782
Cellular growth during early malnutrition.
Pediatrics. 1971 Jun;47(6):969-78 PMID: 5141766
Fetal growth retardation produced by experimental placental insufficiency in the rhesus monkey. I. Body weight, organ size.
Biol Neonate. 1971;18(5):379-94 PMID: 5005913
INTRAUTERINE GROWTH AS ESTIMATED FROM LIVEBORN BIRTH-WEIGHT DATA AT 24 TO 42 WEEKS OF GESTATION.
Pediatrics. 1963 Nov;32:793-800 PMID: 14075621
CHRONIC FETAL DISTRESS AND PLACENTAL INSUFFICIENCY.
Biol Neonat. 1963;5:215-65 PMID: 14081642
GROWTH AND DEVELOPMENT OF TWINS OF DISSIMILAR SIZE AT BIRTH.
Pediatrics. 1964 Mar;33:327-33 PMID: 14129079
EXPERIMENTAL GROWTH RETARDATION IN THE FOETAL RAT.
J Pathol Bacteriol. 1964 Jul;88:1-13 PMID: 14194979
MALNUTRITION: PROBABLE CAUSE OF FETAL GROWTH RETARDATION.
Arch Pathol. 1965 Mar;79:284-91 PMID: 14246208
THE RELATIONSHIP BETWEEN INTELLIGENCE AND BIRTH WEIGHT IN TWINS.
Neurology. 1965 Apr;15:341-7 PMID: 14280597

Article Info

Journal

Journal of clinical pathology

Abbr.

J Clin Pathol

ISSN

0021-9746

DOI

10.1136/jcp.25.10.867

Published

1972-10-00

Pages

867-71

Language

English

Region

England

NLM ID

0376601

PMCID

PMC477537

Subset

External Links

PubMed source DOI: 10.1136/jcp.25.10.867 PMC Full Text View journal details

Analysis Services

Increased brain weight-liver weight ratio as a necropsy sign of intrauterine undernutrition.

Contact

WeChat Official Account