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PMID: 464593 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Effects of miconazole and dodecylimidazole on sterol biosynthesis in Ustilago maydis.

Antimicrobial agents and chemotherapy ·Vol. 15 ·No. 4 ·1979-04-00 ·Pages 603-7

Henry MJ, Sisler HD

Abstract

Miconazole at minimal fungitoxic concentrations inhibits ergosterol biosynthesis in sporidia of Ustilago maydis by interference with sterol C14 demethylation. The action is analogous to that of the fungicides triarimol and fenarimol. The fungicide 1-dodecylimidazole at low concentrations (0.1 to 0.25 mug/ml) inhibits sterol C14 demethylation; however, at higher concentrations (1.0 mug/ml or greater) it also inhibits 2,3-oxidosqualene cyclization and subsequent transmethylation. It is postulated that this diversity of effects of 1-dodecylimidazole results from binding of the inhibitor to sterol carrier protein(s).

MeSH Terms

Basidiomycota/metabolism Imidazoles/pharmacology Miconazole/pharmacology Phytosterols/biosynthesis Spores, Fungal/metabolism Ustilago/drug effects,metabolism

Chemicals

Imidazoles Phytosterols Miconazole

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Henry M J

Sisler H D

References (15)

15 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.15.4.603

Published

1979-04-00

Pages

603-7

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC352718

Subset

External Links

PubMed source DOI: 10.1128/AAC.15.4.603 PMC Full Text View journal details

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Effects of miconazole and dodecylimidazole on sterol biosynthesis in Ustilago maydis.

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