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PMID: 463069 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Increased production of endogenous pyrogen and lysozyme by blood monocytes in sarcoidosis.

The Yale journal of biology and medicine ·Vol. 52 ·No. 3 ·1979-00-00 ·Pages 247-56

Bodel PT, Major PT, Gee JB

Abstract

Blood monocytes from patients with sarcoidosis were incubated in vitro, and secretion of endogenous pyrogen (EP), the protein which mediates fever, and lysozyme (L) were measured. After incubation with endotoxin, monocytes from 5 patients with sarcoidosis released twice as much EP as did monocytes from normal individuals (p < .001). Initial 24-hr secretion of L by monocytes from 6 of 11 additional patients with sarcoidosis exceeded the normal range of values for cells from 11 age- and sex-matched control individuals. Cells with initially augmented secretion rates continued to secrete increased amounts of L for 3 days. A correlation was noted between in vitro secretion of L by monocytes and serum levels of L in the same patient. These studies indicate that circulating mononuclear cells in some patients with sarcoidosis have an increased capacity to secrete EP and/or L prior to tissue localization.

MeSH Terms
Adolescent Adult Endotoxins/pharmacology Female Humans In Vitro Techniques Male Middle Aged Monocytes/enzymology,metabolism Muramidase/blood Pyrogens/blood Sarcoidosis/blood,enzymology Time Factors
Chemicals
Endotoxins Pyrogens Muramidase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bodel P T
Major P T
Gee J B
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24 references, click to expand
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Article Info
Journal
The Yale journal of biology and medicine
Abbr.
Yale J Biol Med
ISSN
0044-0086
Published
1979-00-00
Pages
247-56
Language
English
Region
United States
NLM ID
0417414
PMCID
PMC2595454
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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