Influence of serum and calcium on the bactericidal activity of gentamicin and carbenicillin on Pseudomonas aeruginosa.

Applied microbiology ·Vol. 23 ·No. 4 ·1972-04-00 ·Pages 775-9

Davis SD, Iannetta A

Abstract

Because calcium was found to be antagonistic in vitro to the activity of colistin and polymyxin B on Pseudomonas aeruginosa, the effects of calcium and serum on gentamicin and carbenicillin were also examined. Serum was antagonistic to gentamicin in antibiotic tube dilution tests on five strains of P. aeruginosa. Serum was not antagonistic to carbenicillin in tube dilution tests. Physiologic concentrations of calcium antagonized the activity of gentamicin but not carbenicillin. The antagonism observed with gentamicin was less than that previously seen with colistin. The antagonistic effect of calcium and serum was removed by a chelating agent. Gentamicin and carbenicillin may be more active in vivo against P. aeruginosa than colistin or polymyxin B.

MeSH Terms

Blood Bactericidal Activity Calcium/pharmacology Carbenicillin/antagonists & inhibitors Edetic Acid/pharmacology Escherichia coli/drug effects Gentamicins/antagonists & inhibitors Humans Immune Sera/pharmacology Injections, Intramuscular Kinetics Magnesium/pharmacology Microbial Sensitivity Tests Penicillin Resistance Penicillins/antagonists & inhibitors Pseudomonas aeruginosa/drug effects

Chemicals

Gentamicins Immune Sera Penicillins Edetic Acid Carbenicillin Magnesium Calcium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Davis S D

Iannetta A

References (12)

12 references, click to expand

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Article Info

Journal

Applied microbiology

Abbr.

Appl Microbiol

ISSN

0003-6919

DOI

10.1128/am.23.4.775-779.1972

Published

1972-04-00

Pages

775-9

Language

English

Region

United States

NLM ID

7605802

PMCID

PMC380434

Subset

External Links

PubMed source DOI: 10.1128/am.23.4.775-779.1972 PMC Full Text

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Influence of serum and calcium on the bactericidal activity of gentamicin and carbenicillin on Pseudomonas aeruginosa.

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