4-aminobutyrate:2-oxoglutarate aminotransferase in blood platelets.

Science (New York, N.Y.) ·Vol. 205 ·No. 4407 ·1979-08-17 ·Pages 696-8

White HL

Abstract

Platelet lysates obtained from blood of humans, dogs, and rats catalyzed the transamination of 4-aminobutyrate with 2-oxoglutarate as cosubstrate. Human platelet 4-aminobutyrate:2-oxoglutarate aminotransferase (36.5 +/- 3.2 picomoles per minute per milligram of platelet protein) resembled the brain enzyme in kinetic properties and in response to cofactors and inhibitors.

MeSH Terms

4-Aminobutyrate Transaminase/blood Animals Blood Platelets/enzymology Brain/enzymology Dogs Enzyme Activation/drug effects Humans Kinetics Pyridoxal Phosphate/pharmacology Rats Substrate Specificity Transaminases/blood gamma-Aminobutyric Acid/blood

Chemicals

gamma-Aminobutyric Acid Pyridoxal Phosphate Transaminases 4-Aminobutyrate Transaminase

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

White H L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.462176

Published

1979-08-17

Pages

696-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.462176 View journal details

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4-aminobutyrate:2-oxoglutarate aminotransferase in blood platelets.

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