Antibodies against testicular germinal cells in lepromatous leprosy.

Clinical and experimental immunology ·Vol. 17 ·No. 1 ·1974-05-00 ·Pages 51-9

Wall JR, Wright DJ

Abstract

暂无摘要

Keywords

Age Factors Antibodies--analysis Asia Biology Developing Countries Ethnic Groups Examinations And Diagnoses Genital Effects Male Genitalia Genitalia Male Germ Cells Histology Immunity Immunologic Factors Laboratory Examinations And Diagnoses Laboratory Procedures Malaysia Physiology Southeastern Asia Spermatozoa--analysis Testis Urogenital System

MeSH Terms

Adolescent Adult Aged Autoantibodies BCG Vaccine Complement Fixation Tests Cross Reactions Female Humans Immunoglobulin G Leprosy/immunology Male Middle Aged Mycobacterium bovis/immunology Orchitis/immunology Spermatocytes/immunology Spermatogonia/immunology Testis/cytology,immunology

Chemicals

Autoantibodies BCG Vaccine Immunoglobulin G

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wall J R

Wright D J

Other Abstracts

eng

Testicular germinal cell antibodies were found in 44 of 59 patients with lepromatous leprosy and in 4 of 10 patients with tuberculoid disease. A similar pattern was found in 12 of 262 controls and normal subjects. The antibody was found to be of the IgG class and 40 of 49 of these antibodies were shown to be complement fixing. Spermatozoal antibodies were detected in 12 patients, but no ovarian antibodies were found in any specimen. There was no close correlation between erythema nodosum leprosum and testicular antibodies. It was found that the characteristic of the testicular antibody in leprosy was its ability to be absorbed by Mycobacterium BCG suspension suggesting that this is another antibody induced by infection. A similar fluorescent pattern was seen in some patients who did not have leprosy, but in these cases, it could not be abolished with BCG. It is concluded that autoimmunity may be 1 of the factors involved in the pathogenesis of orchitis in leprosy.

References (24)

24 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1974-05-00

Pages

51-9

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1554063

Subset

External Links

PubMed source PMC Full Text View journal details

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Antibodies against testicular germinal cells in lepromatous leprosy.

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