Effect of R-factor-mediated genes on some surface properties of Escherichia coli.

Antimicrobial agents and chemotherapy ·Vol. 6 ·No. 6 ·1974-12-00 ·Pages 666-71

Curtis NA, Richmond MH

Abstract

The plasmid RP1 was shown to contain a genetic region (the irp region) responsible for influencing the intrinsic resistance of Escherichia coli to penicillins but not to cephalosporins. Mutants in which the irp genes are inactive were isolated. RP1 carrying functional irp genes protected E. coli AS19 against lysozyme lysis and also enhanced resistance to actinomycin D, to nalidixic acid, and to rifampin. This plasmid also phenotypically repaired the hypersensitivity to penicillins of strain AS19, and also that of E. coli envA mutants. Similar regions were not detected on the plasmids R1 and R55.

MeSH Terms

Anti-Bacterial Agents/pharmacology Drug Resistance, Microbial Escherichia coli/drug effects Extrachromosomal Inheritance Genes Muramidase/pharmacology Mutation Phenotype Surface Properties

Chemicals

Anti-Bacterial Agents Muramidase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Curtis N A

Richmond M H

References (13)

13 references, click to expand

Mutant drug resistant factors of high transmissibility.
Nature. 1967 May 27;214(5091):885-7 PMID: 6054969
Resistance of Escherichia coli to tetracyclines. Changes in permeability to tetracyclines in Escherichia coli bearing transferable resistance factors.
Biochem J. 1967 Oct;105(1):371-8 PMID: 4861886
Effective elimination of drug resistance and sex factors in Escherichia coli by sodium dodecyl sulfate.
J Bacteriol. 1968 Mar;95(3):1078-89 PMID: 4868353
Mutants of Escherichia coli permeable to actinomycin.
Proc Natl Acad Sci U S A. 1967 Dec;58(6):2315-20 PMID: 4173585
Mutant of Escherichia coli with anomalous cell division and ability to decrease episomally and chromosomally mediated resistance to ampicillin and several other antibiotics.
J Bacteriol. 1969 Mar;97(3):1334-42 PMID: 4887513
Sensitivity of Pseudomonas aeruginosa to antibiotics: emergence of strains highly resistant to carbenicillin.
Lancet. 1969 Aug 30;2(7618):448-52 PMID: 4183901
Intergeneric transfer of a beta-lactamase gene between Ps. aeruginosa and E. coli.
Nature. 1970 Jun 6;226(5249):952-4 PMID: 4910935
Some cephalosporins in clinical use and their structure-activity relationships.
Postgrad Med J. 1970 Oct;:Suppl:9-13 PMID: 4922713
High level transferable resistance to gentamicin.
J Antibiot (Tokyo). 1971 Feb;24(2):137-9 PMID: 4927255
Properties of a R factor which originated in Pseudomonas aeruginosa 1822.
J Bacteriol. 1972 May;110(2):529-37 PMID: 4336689
R-factor mediated resistance to penicillins which does not involve a beta-lactamase.
J Gen Microbiol. 1973 Nov;79(1):163-6 PMID: 4204236
Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate.
Antimicrob Agents Chemother. 1972 Apr;1(4):283-8 PMID: 4208895
The interplay of beta-lactamases and intrinsic factors in the resistance of gram-negative bacteria to penicillins and cephalosporins.
Ann N Y Acad Sci. 1974 May 10;235(0):553-68 PMID: 4528040

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.6.6.666

Published

1974-12-00

Pages

666-71

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC444716

Subset

External Links

PubMed source DOI: 10.1128/AAC.6.6.666 PMC Full Text View journal details

Analysis Services

Effect of R-factor-mediated genes on some surface properties of Escherichia coli.

Contact

WeChat Official Account