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PMID: 4597731 Published · ppublish English Journal Article

Studies on the action of nalidixic acid in the yeast Saccharomyces cerevisiae.

Antimicrobial agents and chemotherapy ·Vol. 3 ·No. 5 ·1973-05-00 ·Pages 562-7

Michaels CA, Blamire J, Goldfinger B, Marmur J

Abstract

The effect of the antibiotic nalidixic acid on macromolecular metabolism in the yeast Saccharomyces cerevisiae has been studied. It was found that, upon the addition of nalidixic acid to a logarithmically growing culture, there is a transient inhibition of total cell ribonucleic acid, deoxyribonucleic acid, and protein synthesis, after which the cells show an almost complete recovery. In addition, there is no preferential inhibition of yeast mitochondrial deoxyribonucleic acid synthesis.

MeSH Terms
Centrifugation, Density Gradient DNA/biosynthesis Fungal Proteins/biosynthesis Nalidixic Acid/pharmacology RNA/biosynthesis Saccharomyces cerevisiae/drug effects,metabolism Spheroplasts
Chemicals
Fungal Proteins Nalidixic Acid RNA DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Michaels C A
Blamire J
Goldfinger B
Marmur J
References (19)
19 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.3.5.562
Published
1973-05-00
Pages
562-7
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC444458
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.3.5.562 PMC Full Text View journal details
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