Canine cyclic neutropenia. A stem cell defect.

The Journal of clinical investigation ·Vol. 53 ·No. 3 ·1974-03-00 ·Pages 950-3

Weiden PL, Robinett B, Graham TC, Adamson J, Storb R

Abstract

Two normal collie dogs were given 1,200 R total body irradiation followed by successful marrow grafts from their grey collie littermates with cyclic hematopoiesis. During observation periods of 97 and 41 days after grafting, both previously normal recipients showed regular cyclic fluctuations of their granulocyte and reticulocyte counts similar to those observed in their donors. These findings suggest that canine cyclic neutropenia is due to a defect in the marrow stem cell.

MeSH Terms

Agranulocytosis/etiology,therapy,veterinary Animals Bone Marrow/radiation effects Bone Marrow Cells Bone Marrow Diseases/complications Bone Marrow Transplantation Cobalt Radioisotopes Dogs Erythrocyte Count Hematopoietic Stem Cells Histocompatibility Testing Leukocyte Count Radiation Effects Reticulocytes Species Specificity Time Factors Transplantation, Homologous

Chemicals

Cobalt Radioisotopes

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Weiden P L

Robinett B

Graham T C

Adamson J

Storb R

References (6)

6 references, click to expand

Cyclic neutropenia in grey collie dogs.
Blood. 1967 Apr;29(4):452-61 PMID: 6067150
Marrow grafts between canine siblings matched by serotyping and mixed leukocyte culture.
J Clin Invest. 1971 Jun;50(6):1272-5 PMID: 4931083
Mixed leukocyte cultures in dogs. A microtechnique using gradient-purified cells.
Transplantation. 1973 Jun;15(6):642-5 PMID: 4268479
Studies of neutrophil production and turnover in grey collie dogs with cyclic neutropenia.
J Clin Invest. 1972 Aug;51(8):2190-6 PMID: 5054471
Cyclic hematopoiesis: the mechanism of cyclic neutropenia in grey collie dogs.
J Clin Invest. 1972 Aug;51(8):2197-204 PMID: 5054472
Aplastic anaemia treated by marrow transplantation.
Lancet. 1972 Feb 5;1(7745):284-9 PMID: 4109931

Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI107636

Published

1974-03-00

Pages

950-3

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC333078

Subset

External Links

PubMed source DOI: 10.1172/JCI107636 PMC Full Text View journal details

Analysis Services

Canine cyclic neutropenia. A stem cell defect.

Contact

WeChat Official Account