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PMID: 4587612 Published · ppublish English Journal Article

malB region in Escherichia coli K-12: characterization of new mutations.

Journal of bacteriology ·Vol. 117 ·No. 1 ·1974-01-00 ·Pages 40-7

Hofnung M, Hatfield D, Schwartz M

Abstract

Phenotypic characterization and mapping of more than 50 Mal(-) mutations located in the malB region lead one to divide the site for Mal(-)lambdas mutations (formerly called gene malB) in that region, into two adjacent genetic segments malJ and malK. malJ and malK are both involved in maltose permeation. It is suggested that (i) malK and lamB, the only known gene specifically involved in phage lambda adsorption (20), constitute an operon of polarity malK lamB. (ii) malJ and malK correspond to two different genes, and (iii) a promoter for the malK lamB operon is located between malJ and malK. Since lambda receptors and maltose permease are inducible by maltose and absent in malT mutants, it is likely that the expression of the malK lamB operon is controlled by the product of gene malT, the positive regulatory gene of the maltose system.

MeSH Terms
Adsorption Carbon Radioisotopes Chromosome Mapping Coliphages Conjugation, Genetic Crosses, Genetic Escherichia coli/enzymology,metabolism Genes, Regulator Maltose/metabolism Membrane Transport Proteins/metabolism Mutagens Mutation Nitrosoguanidines Operon Recombination, Genetic Transduction, Genetic
Chemicals
Carbon Radioisotopes Membrane Transport Proteins Mutagens Nitrosoguanidines Maltose
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hofnung M
Hatfield D
Schwartz M
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21 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.117.1.40-47.1974
Published
1974-01-00
Pages
40-7
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC246522
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.117.1.40-47.1974 PMC Full Text View journal details
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