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PMID: 458555 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Role of concentration-dependent plasma protein binding in disopyramide disposition.

Journal of pharmacokinetics and biopharmaceutics ·Vol. 7 ·No. 1 ·1979-02-00 ·Pages 29-46

Meffin PJ, Robert EW, Winkle RA, Harapat S, Peters FA, Harrison DC

Abstract

暂无摘要

MeSH Terms

Blood Proteins/metabolism Disopyramide/administration & dosage,blood Humans Kinetics Models, Biological Protein Binding Pyridines/blood

Chemicals

Blood Proteins Pyridines Disopyramide

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Meffin P J

Robert E W

Winkle R A

Harapat S

Peters F A

Harrison D C

References (17)

17 references, click to expand

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The pharmacokinetics of Norpace.
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Binding of anilide-type local anesthetics in human plasma. I. Relationships between binding, physicochemical properties, and anesthetic activity.
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Pharmacokinetics of the antiarrhythmic disopyramide in healthy humans.
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The pharmacokinetics of disopyramide following myocardial infarction with special reference to oral and intravenous dose regimens.
J Int Med Res. 1976;4(1 Suppl):49-53 PMID: 1026529
Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equations which have been fitted to the data.
J Pharmacokinet Biopharm. 1976 Oct;4(5):443-67 PMID: 1003329
The effects of urine pH and plasma protein binding on the renal clearance of disopyramide.
Clin Pharmacokinet. 1977 Sep-Oct;2(5):373-83 PMID: 21054
Disopyramide phosphate: pharmacokinetic and pharmacologic relationships of a new antiarrhythmic agent.
Arch Int Pharmacodyn Ther. 1971 May;191(1):162-88 PMID: 4104224
Statistical estimations in pharmacokinetics.
J Pharmacokinet Biopharm. 1974 Apr;2(2):123-48 PMID: 4427218
High-pressure liquid chromatographic analysis of drugs in biological fluids. III. Analysis of disopyramide and its mono-N-dealkylated metabolite in plasma and urine.
J Chromatogr. 1977 Feb 21;132(3):503-10 PMID: 885947
Clinical pharmacokinetics of antiarrhythmic drugs.
Prog Cardiovasc Dis. 1977 Nov-Dec;20(3):217-42 PMID: 335439
[Pharmacokinetic and metabolic study of disopyramide in oral and intravenous administration].
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Nonlinear plasma level response to high doses of naproxen.
Clin Pharmacol Ther. 1974 Mar;15(3):261-6 PMID: 4815951
A safe method for rapidly achieving plasma concentration plateaus.
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Article Info

Journal

Journal of pharmacokinetics and biopharmaceutics

Abbr.

J Pharmacokinet Biopharm

ISSN

0090-466X

DOI

10.1007/BF01059439

Published

1979-02-00

Pages

29-46

Language

English

Region

United States

NLM ID

0357115

Subset

External Links

PubMed source DOI: 10.1007/BF01059439

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Role of concentration-dependent plasma protein binding in disopyramide disposition.

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