Rapid microbiological assay for 5-fluorocytosine.

British medical journal ·Vol. 4 ·No. 5889 ·1973-11-17 ·Pages 380-2

Schiavone DJ, Page MD, Dawborn JK

Abstract

A microbiological assay was developed for 5-fluorocytosine based on inhibition by the drug of the fall in pH produced by Candida albicans in a synthetic liquid culture medium. Serum and urine levels of the drug could be measured reproducibly in four hours.

MeSH Terms

Antifungal Agents/analysis Biological Assay Candida albicans/drug effects Culture Media Cytosine/analysis Flucytosine/analysis,pharmacology Hydrogen-Ion Concentration Time Factors

Chemicals

Antifungal Agents Culture Media Cytosine Flucytosine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Schiavone D J

Page M D

Dawborn J K

References (4)

4 references, click to expand

The metabolism of 5-fluorocytosine-2-14-C and of cytosine-14-C in the rat and the disposition of 5-fluorocytosine-2-14-C in man.
Biochem Pharmacol. 1966 Apr;15(4):435-46 PMID: 5955812
Rapid microbiological assay of antibiotic in blood and other body fluids.
Lancet. 1968 Aug 17;2(7564):375-8 PMID: 4173790
In vitro studies with 5-fluorocytosine.
Appl Microbiol. 1969 Jun;17(6):871-7 PMID: 5797940
The kinetics of 5-fluorocytosine elimination in man.
Aust N Z J Med. 1972 May;2(2):153-8 PMID: 4507092

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.4.5889.380

Published

1973-11-17

Pages

380-2

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1587823

Subset

External Links

PubMed source DOI: 10.1136/bmj.4.5889.380 PMC Full Text

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Rapid microbiological assay for 5-fluorocytosine.

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