Mutagenic effect of temperature-sensitive mutants of gene 42 (dCMP hydroxymethylase) of bacteriophage T4.

Journal of virology ·Vol. 12 ·No. 1 ·1973-07-00 ·Pages 199-201

Chiu CS, Greenberg GR

Abstract

Certain temperature-sensitive mutants of gene 42 of bacteriophage T4 increase the reversion rates of some rII mutants in the same genome by about 4 to 10 times. This effect was usually found at 34 C, an intermediate permissive temperature, but not at 28 C.

MeSH Terms

Coliphages/enzymology,growth & development Cytosine Nucleotides DNA Viruses/enzymology,growth & development Escherichia coli Genes Mutation Temperature Transferases/biosynthesis

Chemicals

Cytosine Nucleotides Transferases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Chiu C S

Greenberg G R

References (8)

8 references, click to expand

Mutagenic DNA polymerase.
Biochem Biophys Res Commun. 1965 Oct 8;21(1):6-8 PMID: 5865492
The structural gene for deoxyribonucleic acid polymerase in bacteriophages T4 and T5.
Proc Natl Acad Sci U S A. 1965 Oct;54(4):1241-8 PMID: 5219829
Evidence for a dual role for the bacteriophage T4-induced deoxycytidine triphosphate nucleotidohydrolase.
Proc Natl Acad Sci U S A. 1966 Oct;56(4):1233-40 PMID: 4291203
Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4.
J Biol Chem. 1972 Nov 25;247(22):7116-22 PMID: 4565077
Antimutagenic DNA polymerases of bacteriophage T4.
Cold Spring Harb Symp Quant Biol. 1968;33:339-44 PMID: 5254574
Evidence for a possible direct role of dCMP hydroxymethylase in T4 phage DNA synthesis.
Cold Spring Harb Symp Quant Biol. 1968;33:351-9 PMID: 4891975
Reversion of frameshift mutations stimulated by lesions in early function genes of bacteriophage T4.
J Virol. 1971 Apr;7(4):460-6 PMID: 4939385
On the role of DNA polymerase in base selection.
Cold Spring Harb Symp Quant Biol. 1966;31:693-7 PMID: 5237208

Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.12.1.199-201.1973

Published

1973-07-00

Pages

199-201

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC355246

Subset

External Links

PubMed source DOI: 10.1128/JVI.12.1.199-201.1973 PMC Full Text View journal details

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Mutagenic effect of temperature-sensitive mutants of gene 42 (dCMP hydroxymethylase) of bacteriophage T4.

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