Glomerular deposition of properdin in Henoch-Schönlein syndrome and idiopathic focal nephritis.

British medical journal ·Vol. 3 ·No. 5875 ·1973-08-11 ·Pages 326-8

Evans DJ, Williams DG, Peters DK, Sissons JG, Boulton-Jones JM, Ogg CS, Cameron JS, Hoffbrand BI

Abstract

Biopsy of renal tissue from four patients with idiopathic focal nephritis and three patients with Henoch-Schönlein syndrome showed that C3 and properdin were deposited with IgA in the glomerular mesangium, C1q could not be detected. These observations suggest that glomerular injury in disorders characterized by mesangial deposits of IgA and C3 is mediated via the properdin system.

MeSH Terms

Biopsy Complement System Proteins Fibrin/metabolism Fluorescent Antibody Technique Glycine/metabolism Glycoproteins/metabolism Humans Immunoglobulin A Immunoglobulin G Kidney Glomerulus/immunology,metabolism Nephritis/immunology,metabolism Properdin/metabolism Purpura/immunology,metabolism

Chemicals

Glycoproteins Immunoglobulin A Immunoglobulin G Properdin Fibrin Complement System Proteins Glycine

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Evans D J

Williams D G

Peters D K

Sissons J G

Boulton-Jones J M

Ogg C S

Cameron J S

Hoffbrand B I

References (12)

12 references, click to expand

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Glomerular deposition of properdin in acute and chronic glomerulonephritis with hypocomplementemia.
J Clin Invest. 1971 Mar;50(3):642-9 PMID: 5545124
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C3 inactivating factor in the serum of a patient with chronic hypocomplementaemic proliferative glomerulo-nephritis.
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Focal glomerulonephritis. A study based on renal biopsies.
Q J Med. 1959 Jul;28:329-46 PMID: 14401189
Glomerular and dermal depostion of properdin in systemic lupus erythematosus.
N Engl J Med. 1972 Oct 5;287(14):681-5 PMID: 4115613
The glomerular mesangium. 3. Acute immune mesangial injury: a new model of glomerulonephritis.
J Exp Med. 1973 Mar 1;137(3):553-70 PMID: 4570015
Role of C3b in the breakdown of C3 in hypocomplementaemic mesangiocapillary glomerulonephritis.
Lancet. 1973 Mar 3;1(7801):447-9 PMID: 4120364
Reaction mechanism of the alternative pathway of complement fixation.
Lancet. 1973 Mar 3;1(7801):465-7 PMID: 4120372
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Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.3.5875.326

Published

1973-08-11

Pages

326-8

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1586453

Subset

External Links

PubMed source DOI: 10.1136/bmj.3.5875.326 PMC Full Text

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Glomerular deposition of properdin in Henoch-Schönlein syndrome and idiopathic focal nephritis.

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