Immunoglobulin deposition in liver of patients with active chronic hepatitis and antibody against smooth muscle.

British medical journal ·Vol. 2 ·No. 5867 ·1973-06-16 ·Pages 643-5

Dawkins RL, Joske RA

Abstract

Liver biopsies from 33 patients with miscellaneous liver diseases were studied by direct immunofluorescence. Three patients with active chronic hepatitis possessed a distinctive pattern of staining with anti-IgG conjugate. They were relatively young women and all three possessed the anti-smooth-muscle antibody. In addition, all three were untreated at the time of study. It is suggested that direct immunofluorescence on liver biopsies may help in the investigation of liver disease and that humoral immunity may participate in the pathogenesis of active chronic hepatitis.

MeSH Terms

Adolescent Adult Age Factors Antibodies Antibodies, Anti-Idiotypic Biopsy Chronic Disease Female Fluorescent Antibody Technique Hepatitis/etiology,immunology Humans Immunity Immunoglobulin G/metabolism Liver/immunology Liver Diseases/immunology Male Middle Aged Muscle, Smooth/immunology

Chemicals

Antibodies Antibodies, Anti-Idiotypic Immunoglobulin G

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Dawkins R L

Joske R A

References (7)

7 references, click to expand

Immunoglobulin-containing cells in the liver.
Clin Exp Immunol. 1969 Nov;5(5):499-514 PMID: 4188217
Reaction of human smooth muscle antibody with liver cells.
Nat New Biol. 1971 Aug 11;232(2):186-7 PMID: 4936601
Cell-mediated immunity to a human liver-specific antigen in patients with active chronic hepatitis and primary biliary cirrhosis.
Lancet. 1972 Aug 12;2(7772):296-7 PMID: 4115030
Autoimmune aspects of liver disease.
Br Med Bull. 1972 May;28(2):145-8 PMID: 4562014
Smooth-muscle autoantibodies, viral infections and malignant disease.
Proc R Soc Med. 1972 May;65(5):481-4 PMID: 4563392
The L.E.-cell phenomenon in active chronic viral hepatitis.
Lancet. 1955 Sep 3;269(6888):477-80 PMID: 13252894
Surface antigens of differentiated muscle cells in monolayer demonstrated by immunofluorescence and cytotoxicity.
J Immunol Methods. 1972 Nov;2(1):1-9 PMID: 4139205

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.2.5867.643

Published

1973-06-16

Pages

643-5

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1589647

Subset

External Links

PubMed source DOI: 10.1136/bmj.2.5867.643 PMC Full Text

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Immunoglobulin deposition in liver of patients with active chronic hepatitis and antibody against smooth muscle.

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