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PMID: 4564887 Published · ppublish English Journal Article

Delayed hypersensitivity reactions provoked by ribosomes from acid-fast bacilli. I. Ribosomal isolation, characterization, delayed hypersensitivity, and specificity.

Infection and immunity ·Vol. 6 ·No. 3 ·1972-09-00 ·Pages 258-65

Baker RE, Hill WE, Larson CL

Abstract

Ribosomes and ribosomal subunits of Mycobacterium bovis (strain BCG) and M. smegmatis have been isolated and employed as skin test antigens in guinea pigs sensitized with homologous or heterologous organisms. Ribosomes and ribosomal subunits were found to be potent antigens for skin test purposes, and the 30S subunits were found to be more specific and active than the 50S subunits.

MeSH Terms
Animals Antibody Specificity Antigens, Bacterial/adverse effects Cytoplasm Escherichia coli/cytology,immunology Guinea Pigs Hypersensitivity, Delayed Membranes/analysis Microscopy, Electron Mycobacterium/cytology,immunology Mycobacterium bovis/cytology RNA, Bacterial/analysis Ribosomes/analysis,immunology Skin/pathology Skin Tests Spectrophotometry Time Factors Ultracentrifugation
Chemicals
Antigens, Bacterial RNA, Bacterial
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Baker R E
Hill W E
Larson C L
References (34)
34 references, click to expand
  1. Turnover and exchange of ribosomal proteins from rat liver.
    J Biol Chem. 1972 Jan 10;247(1):98-111 PMID: 5017771
  2. Ribosomal proteins of bacterial cells: strain- and species-specificity.
    J Mol Biol. 1968 Apr 14;33(1):93-107 PMID: 4967207
  3. A comparison of the ability of protoplasm and culture filtrate (PPD) antigens from Mycobacterium tuberculosis, M. kansasii and M. batteyi to elicit delayed reactions in infected guinea pigs.
    Am Rev Respir Dis. 1968 Dec;98(6):1055-7 PMID: 4972214
  4. Species specificity of ribosomal proteins in eucaryotic and procaryotic organisms.
    Biochem Biophys Res Commun. 1969 Nov 20;37(5):767-70 PMID: 4982045
  5. X-ray scattering study of ribosomes from Escherichia coli.
    J Mol Biol. 1969 Aug 28;44(1):89-102 PMID: 4897806
  6. Quantitative study of local passive transfer of tuberculin sensitivity with peritoneal exudate cells in the guinea pig.
    J Immunol. 1958 Sep;81(3):235-41 PMID: 13575819
  7. IMPROVED METHOD FOR THE ISOLATION AND PROPERTIES OF TUBERCULIN ACTIVE PEPTIDES.
    J Biochem. 1963 Dec;54:484-90 PMID: 14099003
  8. Isolation, identification, and classification of proteins of tuberculin and the tubercle bacillus.
    Am Rev Tuberc. 1955 May;71(5):704-21 PMID: 14361981
  9. An approach to the measurement of genetic relatedness among organisms.
    Proc Natl Acad Sci U S A. 1963 Jul;50:156-64 PMID: 13932048
  10. NEW APPROACHES TO BACTERIAL TAXONOMY.
    Annu Rev Microbiol. 1963;17:329-72 PMID: 14147455
  11. THE CHROMOSOMAL SITE SPECIFYING A RIBOSOMAL PROTEIN IN ESCHERICHIA COLI.
    Proc Natl Acad Sci U S A. 1964 Dec;52:1367-74 PMID: 14243510
  12. Properties and fine structure of the ribosomes from Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 1968 Sep;61(1):122-9 PMID: 4972363
  13. A 50's ribosomal determinant: immunological studies correlating function and structure.
    J Mol Biol. 1968 Mar 28;32(3):579-86 PMID: 4868759
  14. Chromosomal location of ribosomal protein cistrons determined by intergeneric bacterial mating.
    J Bacteriol. 1969 Jul;99(1):242-7 PMID: 4895845
  15. Preparation and effect of different adjuvants on the immunogenic activity of mycobacterial ribosomal fraction.
    J Bacteriol. 1967 Oct;94(4):836-43 PMID: 4963785
  16. Resolution and identification of ribosomes from mycobacteria.
    J Bacteriol. 1968 Feb;95(2):310-3 PMID: 4867735
  17. Chemical basis for heterogeneity of ribosomal proteins.
    Proc Natl Acad Sci U S A. 1968 Apr;59(4):1329-36 PMID: 4870863
  18. Delayed hypersensitivity to ribosomal protein from BCG.
    J Immunol. 1971 Oct;107(4):1022-6 PMID: 4999256
  19. Protection against pneumococcal infection by a ribosomal preparation.
    Infect Immun. 1971 Jan;3(1):16-23 PMID: 16557934
  20. Unique protein moieties for 30S and 50S ribosomes of Escherichia coli.
    J Bacteriol. 1969 Jun;98(3):1080-6 PMID: 4892365
  21. Physical and functional heterogeneity of E. coli ribosomes.
    Cold Spring Harb Symp Quant Biol. 1969;34:17-24 PMID: 4909497
  22. Factors affecting immunogenic activity of mycobacterial ribosomal and ribonucleic acid preparations.
    J Bacteriol. 1969 Jul;99(1):42-50 PMID: 4979447
  23. Delayed hypersensitivity induced in guinea pigs with tuberculoprotein from M. bovis (BCG).
    Proc Soc Exp Biol Med. 1969 May;131(1):100-4 PMID: 4890255
  24. Allergenicity of intracellular particles, cell walls, and cytoplasmic fluid from Mycobacterium tuberculosis.
    J Bacteriol. 1960 Nov;80:615-21 PMID: 13751111
  25. Immunological analysis of the proteins of Escherichia coli ribosomes.
    J Mol Biol. 1966 Oct;20(3):447-52 PMID: 4961419
  26. Influence of cell disruption methods on polyuridylic acid dependent polyphenylalanine synthesis by isolated ribosomes of mycobacteria.
    Experientia. 1968 Nov 15;24(11):1109-10 PMID: 4889116
  27. Identification and functional characterization of the protein controlled by the streptomycin-resistant locus in E. coli.
    Nature. 1969 Apr 26;222(5191):333-9 PMID: 4181187
  28. Physical studies of ribosomes from Escherichia coli.
    J Mol Biol. 1969 Sep 14;44(2):263-77 PMID: 4940920
  29. Skin reactions in rabbits sensitized with typical and atypical mycobacteria and tested with homologous and heterologous protoplasm.
    Am Rev Respir Dis. 1966 Dec;94(6):923-32 PMID: 5332111
  30. Immunologic significance of the cell wall of mycobacteria.
    Proc Soc Exp Biol Med. 1958 Jun;98(2):263-5 PMID: 13554613
  31. Purified protoplasmic peptides of mycobacteria: isolation of species-specific peptides from protoplasm of mycobacteria.
    J Bacteriol. 1969 Oct;100(1):195-200 PMID: 5344096
  32. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  33. Identification of a precursor pool of ribosome protein in Escherichia coli.
    J Bacteriol. 1968 Apr;95(4):1355-67 PMID: 4967196
  34. Studies on the allergenicity of various tuberculoprotein derivatives and the adjuvanticity of wax D fractions of Mycobacterium tuberculosis.
    Am Rev Respir Dis. 1969 Nov;100(5):691-8 PMID: 4987093
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.6.3.258-265.1972
Published
1972-09-00
Pages
258-65
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC422525
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.6.3.258-265.1972 PMC Full Text View journal details
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