Spontaneous tranformation of human brain cells grown in vitro and description of associated viurs particles.

Science (New York, N.Y.) ·Vol. 176 ·No. 4042 ·1972-06-30 ·Pages 1420-2

Hooks J, Gibbs CJ, Chopra H, Lewis M, Gajdusek DC

Abstract

A human brain cell culture grown in vitro has spontaneously transformed, as determined by morphology, growth characteristics, and karyotype analysis. Virus particles morphologically akin to oncogenic RNA viruses are present in the transformed cells, which are now in subculture 60.

MeSH Terms

Brain/cytology,microbiology Cell Transformation, Neoplastic Cells, Cultured Creutzfeldt-Jakob Syndrome Humans Karyotyping Microscopy, Electron Oncogenic Viruses/isolation & purification RNA Viruses/isolation & purification

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Hooks J

Gibbs C J

Chopra H

Lewis M

Gajdusek D C

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.176.4042.1420

Published

1972-06-30

Pages

1420-2

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.176.4042.1420 View journal details

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Spontaneous tranformation of human brain cells grown in vitro and description of associated viurs particles.

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