Potentiation of rifampicin and 5-fluorocytosine as antifungal antibiotics by amphotericin B (yeast-membrane permeability-ribosomal RNA-eukaryotic cell-synergism).

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 1 ·1972-01-00 ·Pages 196-9

Medoff G, Kobayashi GS, Kwan CN, Schlessinger D, Venkov P

Abstract

Amphotericin B potentiates the antifungal effects of 5-fluorocytosine and rifampicin, probably by increasing the penetration of these agents through the fungal cytoplasmic membrane.

MeSH Terms

Acrylamides Amphotericin B/pharmacology Antifungal Agents/pharmacology Candida/drug effects Candida albicans/drug effects Carbon Isotopes Cell Membrane Permeability/drug effects Cryptococcus neoformans/drug effects Cytosine/pharmacology Drug Combinations Drug Synergism Electrophoresis Fluorine Microbial Sensitivity Tests RNA/biosynthesis Rifampin/pharmacology Saccharomyces cerevisiae/drug effects Tritium Uracil

Chemicals

Acrylamides Antifungal Agents Carbon Isotopes Drug Combinations Tritium Fluorine Uracil RNA Amphotericin B Cytosine Rifampin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Medoff G

Kobayashi G S

Kwan C N

Schlessinger D

Venkov P

References (14)

14 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.69.1.196

Published

1972-01-00

Pages

196-9

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC427574

Subset

External Links

PubMed source DOI: 10.1073/pnas.69.1.196 PMC Full Text View journal details

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Potentiation of rifampicin and 5-fluorocytosine as antifungal antibiotics by amphotericin B (yeast-membrane permeability-ribosomal RNA-eukaryotic cell-synergism).

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