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PMID: 4544619 Published · ppublish English Comparative Study Journal Article

Thymus-dependent lymphocytes of peripheral blood in leprosy patients.

Infection and immunity ·Vol. 9 ·No. 2 ·1974-02-00 ·Pages 394-9

Lim SD, Kiszkiss DF, Jacobson RR, Choi YS, Good RA

Abstract

Study of the numbers of thymus-derived lymphocytes by the rosette assay (T-RFC) in patients with leprosy reveals that lower than normal numbers of T-RFC are regularly seen in those patients with the active lepromatous form of this disease. Essentially normal numbers of T-RFC were found in inactive lepromatous, borderline, and indeterminate types of leprosy. The lowest percentages and lowest absolute numbers of T-RFC were encountered in patients with lepromatous leprosy resistant to chemotherapy. Patients with lepromatous leprosy complicated by erythema nodosum leprosum show numbers of T-RFC that are more nearly normal than the numbers of T-RFC in patients with uncomplicated lepromatous leprosy. These findings are discussed with respect to the pathogenesis of lepromatous leprosy and the T-RFC deficiency demonstrated in this disease. The possibility that transient defects in T-RFC numbers or function may predispose to lepromatous leprosy is proposed.

MeSH Terms
Adult Aged Animals Blood Cell Count Clofazimine/therapeutic use Dapsone/therapeutic use Erythema Nodosum/complications Erythrocytes Humans Immune Adherence Reaction Leprosy/complications,drug therapy,immunology Middle Aged Phenazines/therapeutic use Sheep T-Lymphocytes
Chemicals
Phenazines Dapsone Clofazimine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Lim S D
Kiszkiss D F
Jacobson R R
Choi Y S
Good R A
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24 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.9.2.394-399.1974
Published
1974-02-00
Pages
394-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC414815
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.9.2.394-399.1974 PMC Full Text View journal details
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