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PMID: 4543529 Published · ppublish English Journal Article

Studies of peripheral blood T-and B-lymphocytes in acute infections.

Infection and immunity ·Vol. 9 ·No. 1 ·1974-01-00 ·Pages 1-7

Niklasson PM, Williams RC

Abstract

E-binding (T) and immunoglobulin-bearing (B) lymphocytes were determined in 22 patients with acute infections. The percentage of T-cells was depressed in most patients in the early stages of disease, whereas the B-cell proportion was usually elevated compared with convalescence and controls. The B-cell increase occurred earlier in a small group of viral or mycoplasmal infections than in bacterial infections. Four patients with unusually high numbers of B-cells had no corresponding increase in EAC3-binding lymphocytes. Almost all lymphocytes from pleural effusion in a patient with tuberculosis were found to be T-cells.

MeSH Terms
Acute Disease Adult Aged Animals B-Lymphocytes/immunology Bacterial Infections/immunology Binding Sites Cell Separation Complement System Proteins Erythrocytes/immunology Female Humans Immune Adherence Reaction Immune Sera Immunoglobulins Infections/immunology Male Middle Aged Mycoplasma Infections/immunology Sheep/immunology T-Lymphocytes/immunology Virus Diseases/immunology
Chemicals
Immune Sera Immunoglobulins Complement System Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Niklasson P M
Williams R C
References (21)
21 references, click to expand
  1. The atypical lymphocyte.
    Am J Med. 1967 Jun;42(6):923-36 PMID: 5338481
  2. Theta isoantigen as a marker of thymus-derived lymphocytes in mice.
    Nature. 1969 Oct 25;224(5217):378-9 PMID: 5343887
  3. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.
    Scand J Clin Lab Invest Suppl. 1968;97:77-89 PMID: 4179068
  4. Lymphoid cellular responses in the blood after immunization in man.
    J Exp Med. 1969 May 1;129(5):849-69 PMID: 5778787
  5. Role of thymus-derived lymphocytes in the secondary humoral immune response in mice.
    Nature. 1970 Jun 27;226(5252):1257-8 PMID: 4192904
  6. Immunoglobulin spots on the surface of rabbit lymphocytes.
    J Exp Med. 1970 Nov;132(5):1001-18 PMID: 4919141
  7. The mitogenic effects of endotoxin and staphylococcal enterotoxin B on mouse spleen cells and human peripheral lymphocytes.
    J Immunol. 1970 Dec;105(6):1453-8 PMID: 4921787
  8. Immunoglobulins on the surface of lymphocytes. I. Distribution and quantitation.
    J Exp Med. 1971 Jan 1;133(1):156-67 PMID: 4099713
  9. Immunoglobulins on the surface of lymphocytes. IV. Distribution in hypogammaglobulinemia, cellular immune deficiency, and chronic lymphatic leukemia.
    J Clin Invest. 1971 Nov;50(11):2368-75 PMID: 4999540
  10. Surface-bound immunoglobulin as a marker of B lymphocytes in man.
    Nat New Biol. 1971 Dec 22;234(51):251-2 PMID: 4942988
  11. Requirement of thymus (T) lymphocytes for resistance to listeriosis.
    J Exp Med. 1972 May 1;135(5):1104-12 PMID: 4623315
  12. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.
    J Exp Med. 1972 Aug 1;136(2):207-15 PMID: 4114496
  13. Immunoglobulin and receptors for C3 on lymphocytes from patients with rheumatoid arthritis.
    Arthritis Rheum. 1972 Jul-Aug;15(4):371-80 PMID: 4114708
  14. The elusive T cell receptor.
    Transplant Rev. 1972;10:36-56 PMID: 4403900
  15. Cell surface-associated gamma globulins in lymphocytes. IV. Lack of detection of surface globulin on B-cells and acquisition of surface G globulin by T-cells during primary response.
    J Immunol. 1972 Dec;109(6):1262-71 PMID: 4117549
  16. Studies of T- and B-lymphocytes in patients with connective tissue diseases.
    J Clin Invest. 1973 Feb;52(2):283-95 PMID: 4567306
  17. Combined studies of complement receptor and surface immunoglobulin-bearing cells and sheep erythrocyte rosette-forming cells in normal and leukemic human lymphocytes.
    J Clin Invest. 1973 Feb;52(2):377-85 PMID: 4567307
  18. Thymus-derived rosette-forming cells in various human disease states: cancer, lymphoma, bacterial and viral infections, and other diseases.
    J Clin Invest. 1973 May;52(5):1026-32 PMID: 4540711
  19. Antibody-associated lymphotoxin in acute infection.
    J Clin Invest. 1973 May;52(5):1033-40 PMID: 4700482
  20. Binding of sheep erythrocytes to human lymphocytes. A probable marker of T lymphocytes.
    Scand J Immunol. 1972;1(3):269-80 PMID: 4541574
  21. Lymphoid cells in Hodgkin's disease.
    Nature. 1967 Sep 2;215(5105):1086-8 PMID: 6053439
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.9.1.1-7.1974
Published
1974-01-00
Pages
1-7
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC414755
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.9.1.1-7.1974 PMC Full Text View journal details
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