Induction of T lymphocytes from precursor cells in vitro by a product of the thymus.

The Journal of experimental medicine ·Vol. 138 ·No. 2 ·1973-08-01 ·Pages 479-82

Komuro K, Boyse EA

Abstract

A product of mouse thymus induces cells found in the spleen and bone marrow of nu/nu mice (which lack a thymus), and in 14-day embryonic mouse liver, to differentiate in vitro into T lymphocytes (defined as cells bearing TL and Thy-1 antigens). Thus the in vitro T lymphocyte induction mechanism acts on a cell that is antecedent to any thymus-mediated process.

MeSH Terms

Animals Bone Marrow/immunology Cell Differentiation Embryo, Mammalian Liver/immunology Mice Mice, Inbred Strains Spleen/immunology T-Lymphocytes/immunology Thymus Gland

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Komuro K

Boyse E A

References (8)

8 references, click to expand

Experimental studies on the development of the thymus.
J Exp Med. 1967 Oct 1;126(4):715-26 PMID: 4861748
Surface antigenic markers for distinguishing T and B lymphocytes in mice.
Transplant Rev. 1971;6:52-80 PMID: 4108877
Studies on thymus function. II. Cooperative effect of newborn and embryonic hemopoietic liver cells with thymus function.
J Exp Med. 1970 Sep 1;132(3):601-12 PMID: 4943929
In-vitro demonstration of thymic hormone in the mouse by conversion of precursor cells into lymphocytes.
Lancet. 1973 Apr 7;1(7806):740-3 PMID: 4120721
Functional development of the interacting cells in the immune response. I. Development of T cell and B cell function.
J Immunol. 1972 May;108(5):1379-86 PMID: 4555116
Purification and biological activity of thymosin, a hormone of the thymus gland.
Proc Natl Acad Sci U S A. 1972 Jul;69(7):1800-3 PMID: 4505657
Immunologic properties of mouse thymus cells. Identification of T cell functions within a minor, low-density subpopulation.
J Exp Med. 1972 Dec 1;136(6):1461-77 PMID: 4404879
Thymus: an essential factor in lymphoid repopulation.
Transplant Proc. 1969 Mar;1(1):614-5 PMID: 4400068

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.138.2.479

Published

1973-08-01

Pages

479-82

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2139400

Subset

External Links

PubMed source DOI: 10.1084/jem.138.2.479 PMC Full Text View journal details

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Induction of T lymphocytes from precursor cells in vitro by a product of the thymus.

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