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PMID: 4536707 Published · ppublish English Journal Article

Immune responses in vitro. V. Suppression of M, G, and A plaque-forming cell responses in cultures of primed mouse spleen cells by class-specific antibody to mouse immunoglobulins.

The Journal of experimental medicine ·Vol. 135 ·No. 3 ·1972-03-01 ·Pages 698-710

Pierce CW, Solliday SM, Asofsky R

Abstract

Suppression of Ig class-specific PFC responses by class-specific antibody to mouse immunoglobulin was studied in cultures of spleen cells from immunized mice. In contrast to cultures from normal mice where anti-micro suppressed responses in all Ig classes, anti-micro had progressively less suppressive effect on gamma(1) and gamma(2) responses in cultures from immunized mice with time after immunization. This was most pronounced at 10 days after immunization when anti-micro suppressed gammaM and gammaA responses, but had no or slight effect on gamma(1) or gamma(2) responses which were still suppressed with anti-gamma(1) and anti-gamma(2). These changes in precursor cell susceptibility to anti-micro were antigen specific.

MeSH Terms
Animals Antibodies, Anti-Idiotypic Antibody Formation/drug effects Antibody-Producing Cells Cells, Cultured/immunology Erythrocytes/immunology Goats Immunization Immunoglobulin A/antagonists & inhibitors,biosynthesis Immunoglobulin G/antagonists & inhibitors,biosynthesis Immunoglobulins/antagonists & inhibitors,classification Immunosuppression Therapy In Vitro Techniques Mice Mice, Inbred Strains Rabbits Sheep Spleen/cytology,immunology
Chemicals
Antibodies, Anti-Idiotypic Immunoglobulin A Immunoglobulin G Immunoglobulins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Pierce C W
Solliday S M
Asofsky R
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40 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.135.3.698
Published
1972-03-01
Pages
698-710
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2139143
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.135.3.698 PMC Full Text View journal details
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