Control of growth of a tumor cell by linoleic acid.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 71 ·No. 10 ·1974-10-00 ·Pages 3976-8

Holley RW, Baldwin JH, Kiernan JA

Abstract

The growth of mouse myeloma XS 63.5 cells in cell culture is dependent on serum. Among the several growth factors present in serum, the lipid fraction is highly active. The growth factor(s) provided by the serum lipid fraction can be replaced by unsaturated fatty acids. If XS 63.5 cells are cultured in medium that is low in serum lipids, the cells become quiescent, with most of the cells in the G(1) (or G(0)) phase of the cell cycle. Addition of linoleic acid to such quiescent cells leads to reinitiation of DNA synthesis and growth.

MeSH Terms

Animals Blood Cell Count Cell Division/drug effects Cell Line Culture Media DNA, Neoplasm/analysis,biosynthesis Fluorometry Growth Substances Linoleic Acids/pharmacology Lipids Mice Multiple Myeloma/metabolism Neoplasms, Experimental

Chemicals

Culture Media DNA, Neoplasm Growth Substances Linoleic Acids Lipids

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Holley R W

Baldwin J H

Kiernan J A

References (13)

13 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.71.10.3976

Published

1974-10-00

Pages

3976-8

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC434309

Subset

External Links

PubMed source DOI: 10.1073/pnas.71.10.3976 PMC Full Text View journal details

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Control of growth of a tumor cell by linoleic acid.

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