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PMID: 4526202 Published · ppublish English Comparative Study Journal Article

Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 71 ·No. 6 ·1974-06-00 ·Pages 2169-73

Hart RW, Setlow RB

Abstract

The ability of fibroblasts to perform unscheduled DNA synthesis (a measure of excision-repair) after UV irradiation was measured radioautographically for seven species at several times after several UV fluences. Both the initial rate and the maximum incorporation of [(3)H]dThd increased with the life-span of the species (shrew, mouse, rat, hamster, cow, elephant, man). Unscheduled DNA synthesis was approximately proportional to the logarithm of life-span.

MeSH Terms
Aging Animals Autoradiography Cattle Cricetinae DNA/biosynthesis,radiation effects DNA Repair Elephants Fibroblasts/metabolism,radiation effects Humans Kinetics Longevity Male Mammals Mice Radiation Effects Rats Shrews Thymidine/metabolism Tritium Ultraviolet Rays
Chemicals
Tritium DNA Thymidine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hart R W
Setlow R B
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35 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.71.6.2169
Published
1974-06-00
Pages
2169-73
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC388412
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.71.6.2169 PMC Full Text View journal details
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