Hydrocortisone induction of rat-liver leucyl-transfer RNA and its synthetases.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 12 ·1972-12-00 ·Pages 3567-9

Altman K, Southren AL, Uretsky SC, Zabos P, Acs G

Abstract

Within 3 hr after the intraperitoneal administration of hydrocortisone to female rats, a new leucine-accepting tRNA and a new leucyl-tRNA synthetase activity appear in the liver cytosol. The new isoaccepting tRNA can be acylated only with the synthetase derived from livers of hormone-treated animals. Both components are transient; by 12 hr after hydrocortisone administration, the isoaccepting tRNA and its synthetase disappear from livers of treated animals.

MeSH Terms

Amino Acyl-tRNA Synthetases/isolation & purification,metabolism Animals Carbon Isotopes Chromatography Enzyme Induction/drug effects Female Hydrocortisone/pharmacology Leucine Liver/drug effects,enzymology,metabolism RNA, Transfer/analysis,isolation & purification,metabolism Rats Tritium

Chemicals

Carbon Isotopes Tritium RNA, Transfer Amino Acyl-tRNA Synthetases Leucine Hydrocortisone

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Altman K

Southren A L

Uretsky S C

Zabos P

Acs G

References (4)

4 references, click to expand

A new chromatographic system for increased resolution of transfer ribonucleic acids.
Biochemistry. 1967 Aug;6(8):2507-13 PMID: 4862273
Studies on the effect of cortisone on rat liver transfer ribonucleic acid.
Biochemistry. 1969 Dec;8(12):4806-12 PMID: 5365783
Relation of cortisone and synthesis of ribonucleic acid to induced and developmental enzyme formation.
J Biol Chem. 1963 Apr;238:1548-51 PMID: 13950184
STUDIES ON THE MECHANISM OF DIETHYLSTILBESTROL-INDUCED FORMATION OF PHOSPHOPROTEIN IN MALE CHICKENS.
J Biol Chem. 1964 Jun;239:2079-82 PMID: 14213399

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.69.12.3567

Published

1972-12-00

Pages

3567-9

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC389822

Subset

External Links

PubMed source DOI: 10.1073/pnas.69.12.3567 PMC Full Text View journal details

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Hydrocortisone induction of rat-liver leucyl-transfer RNA and its synthetases.

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