Is prolactin mitogenic for mammary epithelium?

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 7 ·1972-07-00 ·Pages 1693-6

Oka T, Topper YJ

Abstract

Prolactin administration to mature virgin mice leads to prolilferation of epithelium of the mammary gland. In organ culture, prolactin is not mitogenic, but insulin and insulin-free serum are. These observations are reconciled by the finding that insensitive epithelium is sensitized to insulin and/or serum by prolactin treatment in vivo. Thus, it appears that prolactin acts indirectly as a mitogen by rendering the cells susceptible to the aforementioned mitogens.

MeSH Terms

Aminoisobutyric Acids/metabolism Animals Biological Transport/drug effects Blood Cattle DNA/biosynthesis Epithelium/drug effects,metabolism Female Insulin/pharmacology Mammary Glands, Animal/drug effects,metabolism Mice Mice, Inbred Strains Mitogens/pharmacology Mitosis/drug effects Organ Culture Techniques Pregnancy Prolactin/pharmacology Rats Thymidine/metabolism Time Factors Tritium

Chemicals

Aminoisobutyric Acids Insulin Mitogens Tritium Prolactin DNA Thymidine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Oka T

Topper Y J

References (16)

16 references, click to expand

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Somatomedin: proposed designation for sulphation factor.
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.69.7.1693

Published

1972-07-00

Pages

1693-6

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC426780

Subset

External Links

PubMed source DOI: 10.1073/pnas.69.7.1693 PMC Full Text View journal details

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Is prolactin mitogenic for mammary epithelium?

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