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PMID: 4501586 Published · ppublish English Journal Article

Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 3 ·1972-03-00 ·Pages 721-5

Lindahl P, Leary P, Gresser I

Abstract

Mouse interferon preparations enhanced the specific cytotoxicity of sensitized lymphocytes for allogeneic target tumor cells. The factor responsible for the enhancement of cytotoxicity could not be dissociated from the antiviral activity of interferon by standard physicochemical means. Thus, in addition to its well-known antiviral activity, and its effect on cell division, interferon also appears to enhance a specialized cellular function. It is suggested that a common mechanism of action underlies these seemingly different biologic phenomena, and that interferon may play a role in the regulation of fundamental cellular processes.

MeSH Terms
Animals Cells, Cultured Chromium Isotopes Cytotoxicity Tests, Immunologic Immunization Interferons/pharmacology Kinetics Leukemia L1210/immunology Lymphocytes/drug effects,immunology Mice
Chemicals
Chromium Isotopes Interferons
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lindahl P
Leary P
Gresser I
References (24)
24 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.69.3.721
Published
1972-03-00
Pages
721-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC426543
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.69.3.721 PMC Full Text View journal details
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