The possible role of cytochrome P-450 in the liver "first pass elimination" of a beta-receptor blocking drug.

Acta pharmacologica et toxicologica ·Vol. 35 ·No. 3 ·1974-09-00 ·Pages 242-60

Grundin R, Moldéus P, Orrenius S, Borg KO, Skånberg I, von Bahr C

Abstract

暂无摘要

MeSH Terms

Administration, Oral Alprenolol/administration & dosage,metabolism Animals Biological Availability Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System/metabolism Depression, Chemical Imipramine/administration & dosage,pharmacology Injections, Intravenous Liver/metabolism Male Methods Metyrapone/pharmacology Microsomes, Liver/drug effects,enzymology Perfusion Phenobarbital/pharmacology Proadifen/pharmacology Rats Spectrophotometry Time Factors Tritium

Chemicals

Cytochrome P-450 Enzyme Inhibitors Tritium Alprenolol Cytochrome P-450 Enzyme System Proadifen Imipramine Phenobarbital Metyrapone

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Grundin R

Moldéus P

Orrenius S

Borg K O

Skånberg I

von Bahr C

Article Info

Journal

Acta pharmacologica et toxicologica

Abbr.

Acta Pharmacol Toxicol (Copenh)

ISSN

0001-6683

DOI

10.1111/j.1600-0773.1974.tb00744.x

Published

1974-09-00

Pages

242-60

Language

English

Region

Denmark

NLM ID

0370572

Subset

External Links

PubMed source DOI: 10.1111/j.1600-0773.1974.tb00744.x

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The possible role of cytochrome P-450 in the liver "first pass elimination" of a beta-receptor blocking drug.

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