Antenatal irradiation and childhood cancer: causation or coincidence?
A re-analysis of published data from the Oxford Childhood Cancer Survey shows that the frequency of leukaemia and of solid cancers in childhood is greater following antenatal x-radiography, not only in singleton births but also in monozygotic and dizygotic twins. The radiography rate was 10% in singletons and 55% in twins. A similar excess of leukaemia and of solid cancers in the x-rayed with such different rates of radiography is strong evidence for irradiation as the cause. The low observed frequency of malignant disease in Japanese bomb survivors exposed in utero may not be in serious conflict with this conclusion, as has been supposed.
22 references, click to expand
-
Effects of low-dose prenatal irradiation in humans: analysis of Chicago lying-in data and comparison with other studies.Radiat Res. 1974 Mar;57(3):508-44 PMID: 10874964
-
Dose response relationships, particularly in mammalian radiobiology.Annu Rev Nucl Sci. 1965;15:207-40 PMID: 5320658
-
Preconception, intrauterine, and postnatal irradiation as related to leukemia.Natl Cancer Inst Monogr. 1966 Jan;19:347-71 PMID: 5905674
-
Delayed radiation effects in atomic-bomb survivors. Major observations by the Atomic Bomb Casualty Commission are evaluated.Science. 1969 Oct 31;166(3905):569-74 PMID: 4898614
-
Radiation dose effects in relation to obstetric x-rays and childhood cancers.Lancet. 1970 Jun 6;1(7658):1185-8 PMID: 4192374
-
Age-distribution of cancers caused by obstetric x-rays and their relevance to cancer latent periods.Lancet. 1970 Jul 4;2(7662):4-8 PMID: 4193787
-
Childhood cancer in relation to prenatal exposure to atomic-bomb radiation.Lancet. 1970 Nov 14;2(7681):1000-3 PMID: 4098041
-
Prenatal radiation exposure and childhood cancer.Lancet. 1970 Dec 5;2(7684):1189-90 PMID: 4098463
-
Tumour immunology and evolution of the placenta.Lancet. 1970 Dec 5;2(7684):1190-1 PMID: 4098464
-
Prenatal radiation exposure and childhood cancer.Lancet. 1971 Jan 2;1(7688):42-3 PMID: 4099349
-
Mortality in children exposed to the A-bombs while in utero, 1945-1969.Am J Epidemiol. 1971 Jun;93(6):435-42 PMID: 5562716
-
Radiation exposure in utero and mortality.Am J Epidemiol. 1972 Jan;95(1):3 PMID: 5007363
-
Studies of the mortality of A-bomb survivors. 5. Radiation dose and mortality, 1950-1970.Radiat Res. 1972 Jun;50(3):649-98 PMID: 5030091
-
Leukemia from low-level radiation: identification of susceptible children.N Engl J Med. 1972 Jul 20;287(3):107-10 PMID: 5032269
-
The relationship of intra-uterine radiation to subsequent mortality and development of leukemia in children. A prospective study.Am J Epidemiol. 1973 May;97(5):283-313 PMID: 4701674
-
Cancer as a cause of abortions and stillbirths: the effect of these early deaths on the recognition of radiogenic leukaemias.Br J Cancer. 1973 Jun;27(6):465-72 PMID: 4721220
-
Letter: Radiology now--"The 10-day rule".Br J Radiol. 1974 Mar;47(555):198-9 PMID: 4824548
-
Late effects of radiation: carcinogenesis.Br Med Bull. 1973 Jan;29(1):78-83 PMID: 4598452
-
Malignant disease in childhood and diagnostic irradiation in utero.Lancet. 1956 Sep 1;271(6940):447 PMID: 13358242
-
A survey of childhood malignancies.Br Med J. 1958 Jun 28;1(5086):1495-508 PMID: 13546604
-
Prenatal x-ray exposure and childhood cancer.J Natl Cancer Inst. 1962 May;28:1173-91 PMID: 14468031
-
PRENATAL ORIGIN OF CHILDHOOD LEUKEMIA. EVIDENCE FROM TWINS.N Engl J Med. 1964 May 21;270:1082-5 PMID: 14121487
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
