Interaction of biguanides with mitochondrial and synthetic membranes. The role of phospholipids as natural binding sites.

Anilino Naphthalenesulfonates Animals Biguanides/metabolism Binding Sites Carbon Radioisotopes Cattle Egg Yolk Female Kinetics Liposomes Male Membranes/metabolism,ultrastructure Membranes, Artificial Microscopy, Electron Microsomes, Liver/metabolism Mitochondria, Liver/metabolism,ultrastructure Mitochondria, Muscle/metabolism Myocardium Phosphatidylcholines Phospholipids/metabolism Rats Receptors, Drug Spectrometry, Fluorescence Spectrophotometry Sucrose Tritium Ultrasonics

Anilino Naphthalenesulfonates Biguanides Carbon Radioisotopes Liposomes Membranes, Artificial Phosphatidylcholines Phospholipids Receptors, Drug Tritium Sucrose