Effects of D-alpha-aminoadipate on physiologically evoked responses of cat dorsal horn neurones.

Experientia ·Vol. 35 ·No. 3 ·1979-03-15 ·Pages 353-4

Davies J, Dray A

Abstract

Microelectrophoretic administration of D-alpha-aminoadipate reversibly reduced excitatory responses of cat dorsal horn neurones evoked by iontophoretic glutamate and non-noxious peripheral stimuli but did not influence similar responses evoked by noxious peripheral stimuli or iontophoretic substance P.

MeSH Terms

2-Aminoadipic Acid/pharmacology Amino Acids, Dicarboxylic/pharmacology Animals Cats Glutamates/pharmacology Neurons/drug effects,physiology Spinal Cord/cytology,physiology Synapses/drug effects,physiology

Chemicals

Amino Acids, Dicarboxylic Glutamates 2-Aminoadipic Acid

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Davies J

Dray A

References (11)

11 references, click to expand

Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P.
Proc Natl Acad Sci U S A. 1977 Jul;74(7):3081-5 PMID: 331326
Distribution of some synaptic transmitter suspects in cat spinal cord: glutamic acid, aspartic acid, gamma-aminobutyric acid, glycine and glutamine.
J Neurochem. 1967 Apr;14(4):465-72 PMID: 6022905
D-alpha-aminoadipate, alpha, epsilon-diominopimelic acid and HA-966 as antagonists of amino acid-induced and synpatic excitation of mammalian spinal neurones in vivo.
Brain Res. 1978 Jun 16;148(2):543-8 PMID: 207393
The differential sensitivity of spinal interneurones and Renshaw cells to Kainate and N-methyl-D-aspartate.
Exp Brain Res. 1974;21(5):515-8 PMID: 4155370
Spinal interneurone excitation by conformationally restricted analogues of L-glutamic acid.
Nature. 1974 Apr 26;248(5451):804-5 PMID: 4835554
The actions of certain amino acids as neuronal excitants [proceedings].
J Physiol. 1977 Oct;272(1):52P-53P PMID: 592150
Amino acid transmitters in the mammalian central nervous system.
Ergeb Physiol. 1974;69(0):97-188 PMID: 4151806
Effect of substance P in cat dorsal horn neurones activated by noxious stimuli.
Brain Res. 1977 Jun 3;128(1):164-9 PMID: 871905
Pharmacological and electrophysiological studies of morphine and enkephalin on rat supraspinal neurones and cat spinal neurones.
Br J Pharmacol. 1978 May;63(1):87-96 PMID: 206309
D-alpha-Aminoadipate as a selective antagonist of amino acid-induced and synaptic excitation of mammalian spinal neurones.
Nature. 1977 Dec 22-29;270(5639):743-5 PMID: 22820
Effects of substance P on functionally identified units in cat spinal cord.
Brain Res. 1976 Sep 24;114(3):439-51 PMID: 953765

Article Info

Journal

Experientia

Abbr.

Experientia

ISSN

0014-4754

DOI

10.1007/BF01964348

Published

1979-03-15

Pages

353-4

Language

English

Region

Switzerland

NLM ID

0376547

Subset

External Links

PubMed source DOI: 10.1007/BF01964348

Analysis Services

Effects of D-alpha-aminoadipate on physiologically evoked responses of cat dorsal horn neurones.

Contact

WeChat Official Account