Home LiteratureArticle Details
PMID: 4439869 Published · ppublish English Journal Article

Plasma levels of lidocaine during combined treatment with phenytoin and procainamide.

European journal of clinical pharmacology ·Vol. 7 ·No. 6 ·1974-10-04 ·Pages 455-9

Karlsson E, Collste P, Rawlins MD

Abstract

暂无摘要

MeSH Terms
Aged Alanine Transaminase/blood Alkaline Phosphatase/blood Animals Aspartate Aminotransferases/blood Blood Pressure/drug effects Dogs Drug Interactions Female Humans L-Lactate Dehydrogenase/blood Lidocaine/adverse effects,blood,therapeutic use Male Middle Aged Motor Activity/drug effects Myocardial Infarction/drug therapy Phenytoin/pharmacology Procainamide/pharmacology Salivation/drug effects Seizures/chemically induced Spectrometry, Fluorescence Vomiting/chemically induced
Chemicals
Phenytoin Lidocaine L-Lactate Dehydrogenase Aspartate Aminotransferases Alanine Transaminase Alkaline Phosphatase Procainamide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Karlsson E
Collste P
Rawlins M D
References (19)
19 references, click to expand
  1. Treatment of cardiac arrhythmias with phenytoin.
    Br Med J. 1969 Nov 1;4(5678):270-3 PMID: 5345937
  2. The metabolic conversion of 5, 5-diphenyl hydantoin to 5-(p-hydroxyphenyl)-5-phenyl hydantoin.
    J Pharmacol Exp Ther. 1957 Jan;119(1):1-11 PMID: 13457357
  3. The determination of lidocaine and prilocaine in whole blood by gas chromatography.
    Anesthesiology. 1968 Jan-Feb;29(1):110-2 PMID: 5634553
  4. The effect of phenyramidol on the metabolism of diphenylhydantoin.
    Clin Pharmacol Ther. 1967 Jul-Aug;8(4):554-6 PMID: 4951971
  5. Depression of prahydroxylation of diphenylhydantoin by antituberculosis chemotherapy.
    Neurology. 1966 Jun;16(6):594-602 PMID: 5949235
  6. Micromethod for the determination of diphenylhydantoin in plasma and cerebrospinal fluid--a comparison between a gas chromatographic and a spectrophotometric method.
    Scand J Clin Lab Invest. 1972 May;29(3):281-7 PMID: 5037625
  7. Factors affecting drug metabolism.
    Ann N Y Acad Sci. 1971 Jul 6;179:43-66 PMID: 4398309
  8. Procainamide dosage schedules, plasma concentrations, and clinical effects.
    JAMA. 1971 Mar 1;215(9):1454-60 PMID: 5107621
  9. Sinoatrial arrest: an interaction between phenytoin and lignocaine.
    Br Med J. 1971 Mar 20;1(5750):645 PMID: 5548842
  10. Metabolism of procainamide in rhesus monkey and man.
    Clin Pharmacol Ther. 1972 May-Jun;13(3):366-71 PMID: 4623713
  11. Sinoatrial arrest due to lidocaine in a patient receiving guinidine.
    Chest. 1972 Jun;61(7):683-5 PMID: 5031766
  12. Plasma diphenylhydantoin values after oral and intramuscular administration of diphenylhydantoin.
    Neurology. 1973 Mar;23(3):311-7 PMID: 4735181
  13. Identification of 5-(3,4-dihydroxyphenyl)-5-phenylhydantoin as a metabolite of 5,5-diphenylhydantoin (phenytoin) in rats and man.
    Pharmacology. 1972;7(3):129-37 PMID: 5054584
  14. Plasma protein binding of diphenylhydantoin in man. Interaction with other drugs and the effect of temperature and plasma dilution.
    Clin Pharmacol Ther. 1970 Nov-Dec;11(6):846-55 PMID: 4394754
  15. The physiological disposition and cardiac effects of procaine amide.
    J Pharmacol Exp Ther. 1951 May;102(1):5-15 PMID: 14832740
  16. Prilocaine. An experimental study in man of a new local anaesthetic with special regards to efficacy, toxicity and excretion.
    Acta Chir Scand Suppl. 1966;358:1-82 PMID: 5330040
  17. Inadequate serum levels after intramuscular administration of diphenylhydantoin.
    Neurology. 1973 Mar;23(3):318-24 PMID: 4735182
  18. Interaction between phenobarbital and diphenylhydantoin in animals and in epileptic patients.
    Ann N Y Acad Sci. 1971 Jul 6;179:88-107 PMID: 5285399
  19. The tissue distribution, metabolism and excretion of lidocaine in rats, guinea pigs, dogs and man.
    J Pharmacol Exp Ther. 1972 Feb;180(2):454-63 PMID: 5010683
Article Info
Journal
European journal of clinical pharmacology
Abbr.
Eur J Clin Pharmacol
ISSN
0031-6970
DOI
10.1007/BF00560358
Published
1974-10-04
Pages
455-9
Language
English
Region
Germany
NLM ID
1256165
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00560358 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2