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PMID: 4426973 Published · ppublish English Journal Article

Glomerular nodules and long-spacing collagen in kidneys of patients with multiple myeloma.

Journal of clinical pathology ·Vol. 27 ·No. 10 ·1974-10-00 ·Pages 800-5

Schubert GE, Adam A

Abstract

Light microscopic examination of the kidneys in 170 patients with multiple myeloma revealed three from patients without diabetes with glomerular nodules that were indistinguishable from those of diabetic glomerular sclerosis. Electron microscopic studies showed the nodules to be deposits of fine-grained material that corresponded to precipitations of protein but lacked the basement-membrane-like material characteristic of nodular glomerulosclerosis in diabetics. What is more, a unique collagen was observed in the marginal area of the nodules and in the periglomerular interstitium. The possible causes of the origin and distribution of this collagen not so far described in the human kidney are discussed.

MeSH Terms
Aged Collagen Humans Kidney/pathology,ultrastructure Kidney Glomerulus/pathology Kidney Neoplasms/pathology Male Microscopy, Electron Middle Aged Multiple Myeloma/pathology Plasmacytoma/pathology
Chemicals
Collagen
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schubert G E
Adam A
References (27)
27 references, click to expand
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Article Info
Journal
Journal of clinical pathology
Abbr.
J Clin Pathol
ISSN
0021-9746
DOI
10.1136/jcp.27.10.800
Published
1974-10-00
Pages
800-5
Language
English
Region
England
NLM ID
0376601
PMCID
PMC475486
Subset
IM
External Links
PubMed source DOI: 10.1136/jcp.27.10.800 PMC Full Text View journal details
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