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PMID: 4412446 Published · ppublish English Journal Article

Chronic tissue insulin resistance following hemorrhagic shock.

Annals of surgery ·Vol. 180 ·No. 4 ·1974-10-00 ·Pages 402-7

Ryan NT, George BC, Egdahl DH, Egdahl RH

Abstract

Metabolism of fat and muscle tissue was measured for 30 days following shock and reinfusion in rabbits. Tissue insulin resistance in the post-shock period was demonstrated by decreased oxidation of glucose and decreased incorporation of glucose into neutral lipid or glycogen during incubation with insulin. In addition, the insulin stimulated incorporation of amino acids into muscle protein was markedly reduced after shock. Conversely, the capacity of muscle to oxidize leucine was enhanced by shock, even in the presence of insulin. Tissue insulin resistance and increased leucine catabolism are likely to contribute to the general metabolic response to shock and trauma.

MeSH Terms
Adipose Tissue/metabolism Amino Acids/metabolism Animals Carbon Dioxide/metabolism Carbon Radioisotopes Female Glucose/metabolism Insulin/pharmacology Insulin Resistance Leucine/metabolism Male Muscles/metabolism Rabbits Shock, Hemorrhagic/metabolism Time Factors
Chemicals
Amino Acids Carbon Radioisotopes Insulin Carbon Dioxide Leucine Glucose
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ryan N T
George B C
Egdahl D H
Egdahl R H
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24 references, click to expand
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Article Info
Journal
Annals of surgery
Abbr.
Ann Surg
ISSN
0003-4932
DOI
10.1097/00000658-197410000-00004
Published
1974-10-00
Pages
402-7
Language
English
Region
United States
NLM ID
0372354
PMCID
PMC1344109
Subset
IM
External Links
PubMed source DOI: 10.1097/00000658-197410000-00004 PMC Full Text View journal details
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