Abnormal autolytic enzyme in a pneumococus with altered teichoic acid composition.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 11 ·1971-11-00 ·Pages 2627-30

Tomasz A, Westphal M

Abstract

Pneumococci in which the choline component of the cell wall teichoic acid was replaced by ethanolamine contain an abnormal autolytic enzyme that has a low molecular weight and low activity in contrast to the enzyme typical of choline-containing bacteria that has a high molecular weight and high activity. The abnormal autolysin can be converted to the normal (cholinetype) enzyme by incubation in vitro with choline-containing cell walls.

MeSH Terms

Amino Alcohols Autolysis Biodegradation, Environmental Carbon Isotopes Cell Wall/analysis,enzymology,metabolism,physiology Choline Culture Media Glycosides/metabolism Hydrogen-Ion Concentration Muramidase/metabolism Phosphoric Acids/metabolism Streptococcus pneumoniae/enzymology,metabolism Teichoic Acids/analysis,metabolism Tritium

Chemicals

Amino Alcohols Carbon Isotopes Culture Media Glycosides Phosphoric Acids Teichoic Acids Tritium Muramidase Choline

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Tomasz A

Westphal M

References (9)

9 references, click to expand

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J Bacteriol. 1966 Dec;92(6):1623-31 PMID: 5958102
Structural and immunological studies on the pneumococcal C polysaccharide.
J Biol Chem. 1967 Feb 10;242(3):463-70 PMID: 4381522
Choline in the cell wall of a bacterium: novel type of polymer-linked choline in Pneumococcus.
Science. 1967 Aug 11;157(3789):694-7 PMID: 4381896
The autolytic enzyme system of Streptococcus faecalis. II. Partial characterization of the autolysin and its substrate.
Biochemistry. 1967 Apr;6(4):1054-65 PMID: 4962053
Biological consequences of the replacement of choline by ethanolamine in the cell wall of Pneumococcus: chanin formation, loss of transformability, and loss of autolysis.
Proc Natl Acad Sci U S A. 1968 Jan;59(1):86-93 PMID: 4385544
Complement.
Annu Rev Biochem. 1969;38:389-414 PMID: 4184995
Properties of a novel pleiotropic bacteriophage-resistant mutant of Staphylococcus aureus H.
J Bacteriol. 1969 Nov;100(2):846-53 PMID: 4242922
Choline-containing teichoic acid as a structural component of pneumococcal cell wall and its role in sensitivity to lysis by an autolytic enzyme.
J Biol Chem. 1970 Jan 25;245(2):287-98 PMID: 4391619
Multiple antibiotic resistance in a bacterium with suppressed autolytic system.
Nature. 1970 Jul 11;227(5254):138-40 PMID: 4393335

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.68.11.2627

Published

1971-11-00

Pages

2627-30

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC389487

Subset

External Links

PubMed source DOI: 10.1073/pnas.68.11.2627 PMC Full Text View journal details

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Abnormal autolytic enzyme in a pneumococus with altered teichoic acid composition.

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