Calcium: is it required for transmitter secretion?

Science (New York, N.Y.) ·Vol. 172 ·No. 3987 ·1971-06-04 ·Pages 1034-6

Quastel DM, Hackett JT, Cooke JD

Abstract

Ethanol multiplies miniature end-plate potential frequency independently of calcium ion concentrations and also multiplies calcium-dependent depolarization-evoked quantal release, to the same extent. This result implies a final common pathway, requiring little or no calcium, for both kinds of transmitter secretion. Chlorpromazine and hypertonicity act similarly to ethanol, but also depress depolarization-secretion coupling.

MeSH Terms

Animals Calcium/physiology Chelating Agents/pharmacology Chlorpromazine/pharmacology Diaphragm Edetic Acid/pharmacology Ethanol/pharmacology Hypertonic Solutions/pharmacology In Vitro Techniques Membrane Potentials/drug effects Mice Neuromuscular Junction/drug effects,physiology Neurotransmitter Agents/metabolism Stimulation, Chemical Sucrose

Chemicals

Chelating Agents Hypertonic Solutions Neurotransmitter Agents Ethanol Sucrose Edetic Acid Calcium Chlorpromazine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Quastel D M

Hackett J T

Cooke J D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.172.3987.1034

Published

1971-06-04

Pages

1034-6

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.172.3987.1034 View journal details

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