Abstract
The protein component of the T-even bacteriophage coat which binds the phage-specific dihydropteroyl polyglutamate has been identified as the phage-induced dihydrofolate reductase. Dihydrofolate reductase activity has been found in highly purified preparations of T-even phage ghosts and phage substructures after partial denaturation. The highest specific enzymatic activity was found in purified tail plate preparations, and it was concluded that this enzyme was a structural component of the phage tail plate. Phage viability was directly correlated with the enzymological properties of the phage tail plate dihydrofolate reductase. All reactions catalyzed by this enzyme which changed the oxidation state of the phage dihydrofolate also inactivated the phage. Properties of two T4D dihydrofolate reductase-negative mutants, wh1 and wh11, have been examined. Various lines of evidence support the view that the product of the wh locus of the phage genome is normally incorporated into the phage tail structure. The effects of various dihydrofolate reductase inhibitors on phage assembly in in vitro complementation experiments with various extracts of conditional lethal T4D mutants have been examined. These inhibitors were found to specifically block complementation when added to extracts which did not contain preformed tail plates. If tail plates were present, inhibitors such as aminopterin, did not affect further phage assembly. This specific inhibition of tail plate formation in vitro confirms the analytical and genetic evidence that this phage-induced "early" enzyme is a component of the phage coat.
MeSH Terms
Aminopterin/pharmacology
Animals
Binding Sites
Coliphages/analysis,drug effects,enzymology,growth & development,immunology,isolation & purification
Escherichia coli
Fluorometry
Folic Acid Antagonists
Formamides
Genes
Genetic Complementation Test
Genetics, Microbial
Immune Sera
Methotrexate/pharmacology
Mutation
NAD/pharmacology
NADP/pharmacology
Rabbits
Solvents
Spectrophotometry
Tetrahydrofolate Dehydrogenase/analysis,metabolism
Urea
Viral Proteins/analysis
Virus Replication/drug effects
Chemicals
Folic Acid Antagonists
Formamides
Immune Sera
Solvents
Viral Proteins
NAD
NADP
Urea
Tetrahydrofolate Dehydrogenase
Aminopterin
Methotrexate
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kozloff L M
Verses C
Lute M
Crosby L K
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22 references, click to expand
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