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PMID: 4392399 Published · ppublish English Journal Article

Cellular metabolism in genetic transformation of pneumococci: requirement for protein synthesis during induction of competence.

Journal of bacteriology ·Vol. 101 ·No. 3 ·1970-03-00 ·Pages 860-71

Tomasz A

Abstract

Metabolic inhibitors have differential effects on various phases of genetic transformation in pneumococci. Evidence is presented suggesting that, in addition to the competence factor, another specific protein or class of proteins is essential for the development of cellular "competence." The precise role of this protein(s) in genetic transformation is not known, but it seems essential for some function subsequent to the interaction of competence factor and cells.

MeSH Terms
Amino Acids/pharmacology Bacterial Proteins/biosynthesis Carbon Isotopes Chloramphenicol/pharmacology Culture Media DNA, Bacterial/biosynthesis Depression, Chemical Floxuridine/pharmacology Glucose/pharmacology Iodoacetates/pharmacology Macromolecular Substances/metabolism Mutation Phenylalanine/metabolism Puromycin/pharmacology RNA, Bacterial/biosynthesis Rifampin/pharmacology Streptococcus pneumoniae/metabolism Thymidine/pharmacology Transformation, Genetic/drug effects Uracil/pharmacology
Chemicals
Amino Acids Bacterial Proteins Carbon Isotopes Culture Media DNA, Bacterial Iodoacetates Macromolecular Substances RNA, Bacterial Floxuridine Phenylalanine Puromycin Uracil Chloramphenicol Glucose Thymidine Rifampin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Tomasz A
References (22)
22 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.101.3.860-871.1970
Published
1970-03-00
Pages
860-71
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC250403
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.101.3.860-871.1970 PMC Full Text View journal details
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