Hydrolysis of bradykinin and its higher homologues by angiotensin-converting enzyme.

The Biochemical journal ·Vol. 141 ·No. 3 ·1974-09-00 ·Pages 915-7

Dorer F, Ryan JW, Stewart JM

Abstract

The hydrolysis of bradykinin and its higher homologues by angiotensin-converting enzyme has been investigated by using an automated ninhydrin technique. The results show an inverse relationship of hydrolysis rate with size and charge of the peptide, which parallels the inactivation in the pulmonary circulation and offers an explanation for the selectivity of metabolism of these kinins by the lungs.

MeSH Terms

Amino Acid Sequence Angiotensin II Animals Bradykinin/metabolism Hydrolysis Lung/enzymology Ninhydrin Peptidyl-Dipeptidase A/metabolism Pulmonary Circulation Swine

Chemicals

Angiotensin II Peptidyl-Dipeptidase A Ninhydrin Bradykinin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Dorer F

Ryan J W

Stewart J M

References (12)

12 references, click to expand

Angiotensin I converting enzyme of the lung.
Circ Res. 1972 Sep;31(9):Suppl 2:51-61 PMID: 4341480
Substrate requirements for angiotensin I conversion in vivo and in vitro.
Circ Res. 1973 Apr;32(4):415-23 PMID: 4349742
The bradykininase activities of extracts of dog lung.
Br J Pharmacol. 1973 Apr;47(4):799-807 PMID: 4723801
Purification and properties of angiotensin-converting enzyme from hog lung.
Circ Res. 1972 Sep;31(3):356-66 PMID: 4341470
Circular dischroism of bradykinin and related peptides.
Biochem J. 1971 Jan;121(2):179-84 PMID: 5117026
Metabolism of angiotensin I in the pulmonary circulation.
Biochem J. 1970 Nov;120(1):221-3 PMID: 4321932
Inactivation of bradykinin in the pulmonary circulation.
Biochem J. 1968 Dec;110(4):795-7 PMID: 5704826
The disappearance of bradykinin and eledoisin in the circulation and vascular beds of the cat.
Br J Pharmacol Chemother. 1967 Jun;30(2):417-24 PMID: 6036419
Electron microscopy of endothelial and epithelial components of the lungs: correlations of structure and function.
Fed Proc. 1973 Sep;32(9):1957-66 PMID: 4353597
Hydrolysis of bradykinin by angiotensin-converting enzyme.
Circ Res. 1974 Jun;34(6):824-7 PMID: 4364999
A circular dichroism study of the secondary structure of bradykinin.
Biochemistry. 1973 Sep 11;12(19):3780-8 PMID: 4363120
Assay of kinins by their effects on blood pressure.
Res Commun Chem Pathol Pharmacol. 1973 Jul;6(1):206-12 PMID: 4733998

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1410915

Published

1974-09-00

Pages

915-7

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1168198

Subset

External Links

PubMed source DOI: 10.1042/bj1410915 PMC Full Text View journal details

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Hydrolysis of bradykinin and its higher homologues by angiotensin-converting enzyme.

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