Oxygen uptake by Treponema pallidum.

Infection and immunity ·Vol. 10 ·No. 1 ·1974-07-00 ·Pages 123-7

Cox CD, Barber MK

Abstract

Virulent Treponema pallidum has been shown to consume O(2) at a rate similar to that of the known aerobic spirochaete, Leptospira. Such O(2) uptake is cyanide sensitive, indicating a functioning cytochrome oxidase. Inhibition of O(2) uptake by azide, chlorpromazine, and amytal further suggests a functioning electron transport system for the oxidation of nicotinamide adenine dinucleotide (reduced) to O(2). Evidence is consistent with the probability that this terminal electron-transport system is coupled to oxidative phosphorylation. The potential significance of these findings is discussed.

MeSH Terms

Amobarbital/pharmacology Anaerobiosis Azides/pharmacology Bacteriological Techniques Chlorpromazine/pharmacology Cyanides/pharmacology Dinitrophenols/pharmacology Electron Transport/drug effects Electron Transport Complex IV/metabolism Leptospira/metabolism NAD/metabolism Oxidative Phosphorylation/drug effects Oxygen Consumption Quinolines Rotenone Spirochaeta/metabolism Treponema pallidum/metabolism

Chemicals

Azides Cyanides Dinitrophenols Quinolines Rotenone NAD Electron Transport Complex IV Amobarbital Chlorpromazine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Cox C D

Barber M K

References (14)

14 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.10.1.123-127.1974

Published

1974-07-00

Pages

123-7

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC414967

Subset

External Links

PubMed source DOI: 10.1128/iai.10.1.123-127.1974 PMC Full Text View journal details

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Oxygen uptake by Treponema pallidum.

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