Regulation of mitochondrial alpha-ketoglutarate metabolism by product inhibition at alpha-ketoglutarate dehydrogenase.

Adenine Nucleotides/metabolism Allosteric Regulation Animals Coenzyme A/pharmacology Guanine Nucleotides/pharmacology Guinea Pigs Ketoglutarate Dehydrogenase Complex/antagonists & inhibitors,metabolism Ketoglutaric Acids/metabolism Ketone Oxidoreductases/metabolism Kinetics Liver/cytology Male Mathematics Mitochondria, Liver/drug effects,enzymology,metabolism Multienzyme Complexes/metabolism NAD/administration & dosage,pharmacology Oxidation-Reduction Oxidative Phosphorylation Phosphoenolpyruvate/pharmacology Rats Succinates/pharmacology

Adenine Nucleotides Guanine Nucleotides Ketoglutaric Acids Multienzyme Complexes Succinates NAD Phosphoenolpyruvate Ketone Oxidoreductases Ketoglutarate Dehydrogenase Complex Coenzyme A