Hormonal control of neutrophil lysosomal enzyme release: effect of epinephrine on adenosine 3',5'-monophosphate.

Science (New York, N.Y.) ·Vol. 183 ·No. 4127 ·1974-03-01 ·Pages 855-7

Ignarro LJ, Paddock RJ, George WJ

Abstract

Human neutrophilic leukocytes release neutral protease and beta-glucuronidase during cell contact with, and phagocytosis of, zymosan particles treated with rheumatoid arthritic serum. Release of lysosomal enzymes is inhibited by epinephrine and adenosine 3',5'-monophosphate (cyclic AMP), but not by phenylephrine or adenosine 5'-monophosphate. Inhibition of enzyme release by epinephrine may be mediated by cyclic AMP because the cyclic AMP in the neutrophils is increased by epinephrine treatment at the time when enzyme release is reduced.

MeSH Terms

Adenosine Monophosphate/pharmacology Arthritis, Rheumatoid/immunology Bucladesine/pharmacology Cyclic AMP/metabolism,pharmacology Depression, Chemical Epinephrine/pharmacology Glucuronidase/metabolism Humans Immune Sera Isoproterenol/pharmacology L-Lactate Dehydrogenase/metabolism Lysosomes/enzymology Neutrophils/cytology,drug effects,enzymology,metabolism Peptide Hydrolases/metabolism Phagocytosis Phentolamine/pharmacology Phenylephrine/pharmacology Theophylline/pharmacology Zymosan

Chemicals

Immune Sera Phenylephrine Adenosine Monophosphate Bucladesine Zymosan Theophylline Cyclic AMP L-Lactate Dehydrogenase Glucuronidase Peptide Hydrolases Isoproterenol Epinephrine Phentolamine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Ignarro L J

Paddock R J

George W J

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.183.4127.855

Published

1974-03-01

Pages

855-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.183.4127.855 View journal details

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Hormonal control of neutrophil lysosomal enzyme release: effect of epinephrine on adenosine 3',5'-monophosphate.

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