Carbon tetrachloride hepatotoxicity: an example of lethal cleavage.

Animals Carbon Radioisotopes Carbon Tetrachloride/metabolism Carbon Tetrachloride Poisoning/metabolism,prevention & control Chemical and Drug Induced Liver Injury/metabolism Cytochrome P-450 Enzyme System/metabolism Cytochrome Reductases/metabolism Cytochrome c Group/metabolism Fatty Acids, Unsaturated/metabolism Free Radicals Glucose-6-Phosphatase/metabolism In Vitro Techniques Lipid Metabolism Liver/metabolism Microsomes, Liver/enzymology Mitochondria, Liver/metabolism NAD Oxidation-Reduction Peroxides/metabolism Proadifen/therapeutic use Protein Biosynthesis Proteins/antagonists & inhibitors Rats Sulfhydryl Compounds/metabolism Time Factors

Carbon Radioisotopes Cytochrome c Group Fatty Acids, Unsaturated Free Radicals Peroxides Proteins Sulfhydryl Compounds NAD Cytochrome P-450 Enzyme System Proadifen Carbon Tetrachloride Cytochrome Reductases Glucose-6-Phosphatase