Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola.

Antimicrobial agents and chemotherapy ·Vol. 4 ·No. 3 ·1973-09-00 ·Pages 294-8

Bucknall RA, Moores H, Simms R, Hesp B

Abstract

Aphidicolin is an antibiotic of novel structure produced by the mold Cephalosporium aphidicola. It is a potent inhibitor of cellular deoxyribonucleic acid synthesis, and it also strongly inhibits the growth of herpes simplex virus both in tissue culture and in the rabbit eye. Aphidicolin is active against iododeoxyuridine-resistant herpes virus, and does not itself readily induce the formation of drug-resistant strains of herpesvirus.

MeSH Terms

Acremonium/metabolism Animals Anti-Bacterial Agents/pharmacology,therapeutic use Antiviral Agents/pharmacology,therapeutic use Cattle Cell Line Cornea Culture Techniques Cytarabine/pharmacology DNA, Viral/biosynthesis Diterpenes/pharmacology,therapeutic use Drug Resistance, Microbial Embryo, Mammalian Humans Idoxuridine/pharmacology Keratitis, Dendritic/drug therapy Kidney Lung Microbial Sensitivity Tests Rabbits Simplexvirus/drug effects

Chemicals

Anti-Bacterial Agents Antiviral Agents DNA, Viral Diterpenes Cytarabine Idoxuridine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Bucknall R A

Moores H

Simms R

Hesp B

References (6)

6 references, click to expand

Herpes keratitis in rabbits: pathogenesis and effect of antiviral nucleosides.
Ann N Y Acad Sci. 1965 Jul 30;130(1):151-67 PMID: 5323378
Clinical studies with systemic administration of antimetabolites of pyrimidine nucleosides in viral infections.
Ann N Y Acad Sci. 1965 Jul 30;130(1):192-208 PMID: 4221776
The effects of substituted benzimidazoles on the growth of viruses and the nucleic acid metabolism of host cells.
J Gen Virol. 1967 Jan;1(1):89-99 PMID: 4293937
Activity of 1-beta-D-arabinofuranosylcytosine hydrochloride against herpes simplex keratitis.
Proc Soc Exp Biol Med. 1962 Dec;111:660-4 PMID: 13995366
SOME BIOLOGIC ASPECTS OF HERPESVIRUS-CELL INTERACTIONS IN THE PRESENCE OF 5-IODO, 2-DESOXYURIDINE (IDU). DEMONSTRATION OF A CYTOTOXIC EFFECT BY HERPESVIRUS.
J Immunol. 1963 Nov;91:582-90 PMID: 14089760
Incorporation of iododeoxyuridine into the deoxyribonucleic acid of mouse Ehrlich-ascites-tumor cells in vivo.
Biochim Biophys Acta. 1960 Apr 8;39:327-31 PMID: 14435161

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.4.3.294

Published

1973-09-00

Pages

294-8

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC444544

Subset

External Links

PubMed source DOI: 10.1128/AAC.4.3.294 PMC Full Text View journal details

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Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola.

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