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PMID: 4356456 Published · ppublish English Journal Article

Suppression of herpes simplex virus infection by phosphonoacetic acid.

Applied microbiology ·Vol. 26 ·No. 3 ·1973-09-00 ·Pages 264-7

Shipkowitz NL, Bower RR, Appell RN, Nordeen CW, Overby LR, Roderick WR, Schleicher JB, Von Esch AM

Abstract

Disodium phosphonoacetate when administered orally or topically to mice experimentally infected with herpes simplex virus was able to significantly reduce the mortality associated with the agent. In addition, this compound was able to reduce herpesvirus lesions on the corneas of infected rabbits.

MeSH Terms
Acetates/administration & dosage,therapeutic use Administration, Oral Administration, Topical Animals Antiviral Agents/administration & dosage,therapeutic use Female Herpes Simplex/drug therapy,mortality Keratitis, Dendritic/drug therapy Mice Ointments Organophosphorus Compounds/administration & dosage,therapeutic use Rabbits Serotyping Simplexvirus/drug effects
Chemicals
Acetates Antiviral Agents Ointments Organophosphorus Compounds
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Shipkowitz N L
Bower R R
Appell R N
Nordeen C W
Overby L R
Roderick W R
Schleicher J B
Von Esch A M
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24 references, click to expand
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Article Info
Journal
Applied microbiology
Abbr.
Appl Microbiol
ISSN
0003-6919
DOI
10.1128/am.26.3.264-267.1973
Published
1973-09-00
Pages
264-7
Language
English
Region
United States
NLM ID
7605802
PMCID
PMC379771
Subset
IM
External Links
PubMed source DOI: 10.1128/am.26.3.264-267.1973 PMC Full Text
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