Hepatitis A: detection by immune electron microscopy of a viruslike antigen associated with acute illness.

Science (New York, N.Y.) ·Vol. 182 ·No. 4116 ·1973-12-07 ·Pages 1026-8

Feinstone SM, Kapikian AZ, Purceli RH

Abstract

Spherical 27-nanometer particles were visualized in stools obtained from hepatitis A patients in the acute phase of the disease. The particle was serologically specific for this disease, and every hepatitis A patient tested demonstrated a serologic response to this antigen. The findings suggest that it is the etiologic agent of hepatitis A.

MeSH Terms

Antibodies, Viral/analysis Antibody Formation Antigen-Antibody Reactions Antigens, Viral/isolation & purification Cross Reactions Feces/microbiology Hepatitis A/immunology,microbiology Hepatitis B Antigens/immunology Hepatovirus/isolation & purification Humans Microscopy, Electron Radioimmunoassay

Chemicals

Antibodies, Viral Antigens, Viral Hepatitis B Antigens

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Feinstone S M

Kapikian A Z

Purceli R H

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.182.4116.1026

Published

1973-12-07

Pages

1026-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.182.4116.1026 View journal details

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Hepatitis A: detection by immune electron microscopy of a viruslike antigen associated with acute illness.

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