Cytomegalovirus: conversion of nonpermissive cells to a permissive state for virus replication.

Science (New York, N.Y.) ·Vol. 181 ·No. 4104 ·1973-09-14 ·Pages 1060-1

St Jeor S, Rapp F

Abstract

Human embryonic kidney cells are epithelioid cells which are normally nonpermissive for in vitro replication of human cytomegalovirus. These cells were converted to a permissive state for the virus by prior treatment with 5-iodo-2'-deoxyuridine. When this method was used, a nonpermissive cell was made permissive to an infecting virus.

MeSH Terms

Cells, Cultured Cytomegalovirus/growth & development,metabolism DNA/biosynthesis DNA, Viral/biosynthesis Embryo, Mammalian Epithelial Cells Humans Idoxuridine/pharmacology Kidney Thymidine/metabolism Tritium Viral Plaque Assay Virus Replication/drug effects

Chemicals

DNA, Viral Tritium DNA Idoxuridine Thymidine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

St Jeor S

Rapp F

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.181.4104.1060

Published

1973-09-14

Pages

1060-1

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.181.4104.1060 View journal details

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Cytomegalovirus: conversion of nonpermissive cells to a permissive state for virus replication.

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